The General Hospital Corporation

Massachusetts Institute of Technology

Canon U.s.a., Inc.

Tufts University

Maria Angela Franceschini

David Alan Boas

Jason Sutin

Stefan A Carp

Bruce R Rosen

Haruo Nakaji

Megan H Blackwell

Sergio Fantini

Davide Tamborini

Erin Buckley

Oleg Shatrovoy

Adriano Peruch

Pei-Yi Lin

Kuan Cheng Wu

Marco Renna

A sensor assembly and sensing method is provided for proximity detection for assessing an attachment state of a sensing probe with respect to a subject. A probe is coupled to an electronic probe controller. The probe includes a proximity sensor having a passive energy storing circuit element, and a biological sensor receptacle configured to receive a biological sensor for sensing a biological characteristic of an object. The electronic probe controller excites a circuit network incorporating the proximity sensor with an excitation signal and determines a characteristic of the circuit network that is excited by the excitation signal. The electronic probe controller further generates a proximity indication indicating whether the probe is attached to the object based on the characteristic of the circuit network.

Proximity detection for assessing sensing probe attachment state

An apparatus, including: a probe to interface with a surface of a tissue; a light source optically coupled to the probe, the light source directing light of at least 1000 nm into the tissue; a detector optically coupled to the probe, the detector to detect light based on scattering of light from the light source in the tissue, and the detector having a light sensitivity in a range of at least 1000 nm; a processor coupled to the detector, the processor to: receive a signal from the detector corresponding to the detected light from the light source, and determine a blood flow measurement from the region of interest using diffuse correlation spectroscopy based on the signal.

System and method for an optical blood flow measurement

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.

System and method for monitoring absolute blood flow

Systems and methods for path length selected diffuse correlation spectroscopy (PLS-DCS) are disclosed. The systems and methods are suitable for measuring dynamics of a target medium. The systems and methods can utilize light sources having a coherence length that is shorter than a path length distribution of the target medium and can utilize a reference optical path to interferometrically detect PLS-DCS signals. The coherence length and reference path length can be selected to provide sensitivity to portions of the target medium that correspond to a desired path length distribution.

Systems and methods for path length selected diffuse correlation spectroscopy

A system and method for non-invasively estimating an absolute blood flow of a vascular region in a subject using optical data are provided. In some aspects, the method includes acquiring optical data from the vascular region using one or more optical sensors placed about the subject, and determining, using the optical data, an index of blood flow and. a blood volume associated with the vascular region. The method also includes computing a blood inflow and a blood outflow using the index of blood flow and the blood volume, and estimating an absolute blood flow using the blood inflow and blood outflow. The method further includes generating a report indicative of the absolute blood flow of the vascular region.

A system and method for non-invasively monitoring intracranial pressure are provided. In some aspects, the method comprises acquiring diffuse correlation spectroscopy data at a temporal resolution greater than a pulsatile frequency of cerebral blood flow of a subject using one or more optical sensors placed about a subject, and determining a pulsatile cerebral blood flow using the acquired data, The method also includes correlating the determined pulsatile cerebral blood flow with physiological data acquired from the subject, and estimating an intracranial pressure based on the correlation. The method further includes generating a report indicative of the estimated intracranial pressure.

System and method for non-invasively monitoring intracranial pressure

There is provided herewith an apparatus, probe, and method for the combination of near-infrared spectroscopy (NIRS) and diffuse correlation spectroscopy (DCS). The apparatus, probe and method allow for the simultaneous detection of NIRS and DCS.

Near-infrared spectroscopy and diffuse correlation spectroscopy device and methods

A method for measuring venous oxygen saturation levels has steps of measuring optical absorption oscillation data at the respiratory frequency at a plurality of wavelengths (). A reduced scattering coefficient and an absorption coefficient are determined for the tissue, with the result that an effective path length can be determined (). Data processing is performed to calculate amplitudes for the absorption oscillation data that are translated into oxygenated and deoxygenated hemoglobin concentrations for the venous compartment (). A method of the invention does not required mechanical ventilation devices or venous perturbation. Additional method steps may entail verifying that the measured absorption oscillation data results from the venous compartment.

Growing community of inventors

Winchester, MA, United States of America

Maria Angela Franceschini