Farmitalia Carlo Erba S.r.l.

Farmitalia Carlo Erba S.p.a.

Farmitalia Carlo Erba

Maria A Cervini

Mario Varasi

Piero Melloni

Aldemio Temperilli

Mauro Gobbini

Enzo Brambilla

Alberto Bonsignori

Roberto Commisso

The present invention relates to compounds having the following formula (I) ##STR1## wherein X represents --O-- or --S--;

Piperazine-substituted 1,4-benzoxazine derivatives and their use in

2-(piperidinylmethyl)-4-phenyl-2,3-dihydro-4H-1,4-benzoxazines useful as

t-alkyl eroline derivatives of formula I are produced ##STR1## wherein (R.sub.1 =H, OCH.sub.3 and R.sub.2 H) or (R.sub.1 +R.sub.2 =a ring bond and R.sub.3 =H, optionally substituted nicotinynoyl or 1-oxo-2-cyclopenten-3-yl); and their pharmaceutically acceptable salts. A process for the preparation of these derivatives from lysergol and a t-alkyl alcohol is also described, as are pharmaceutical compositions containing them.

t-alkyl ergoline derivatives

t-Alkyl ergoline derivatives of formula I are produced ##STR1## wherein (R.sub.1 =H, OCH.sub.3 and R.sub.2 =H) or (R.sub.1 +R.sub.2 =a ring bond and R.sub.3 =H, optionally substituted nicotinoyl or 1-oxo-2-cyclopenten-3-yl); and their pharmaceutically acceptable salts. A process for the preparation of these derivatives from lysergol and a t-alkyl alcohol is also described, as are pharmaceutical compositions containing them.

1-t-butyl ergolines useful in the treatment of cerebral insufficiency

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Cardano al Campo, Italy

Maria A Cervini