Fujifilm Corporation

Toyama Chemical Co., Ltd.

Mari Yamamoto

Takashi Tamura

Hidenobu Kuniyoshi

Hiyoku Nakata

Shinsuke Mizumoto

Yasutaka Baba

Shinji Hagiwara

Hideyasu Fujiwara

Yohei Kubo

Yukihiko Aikawa

Tomoyuki Mashiko

Yuichiro Sato

Shunichi Shiozawa

Kimihiko Sato

Hideki Kurihara

Kimiko Morimoto

The object of the present invention is to provide a compound and a pharmaceutical composition having excellent Syk inhibitory activity. According to the present invention, a nicotinamide derivative represented by the following formula (I) or a salt thereof is provided, wherein (wherein R, R, R, n, and Xhave the same definitions as those described in the specification), and Ris a pyridyl, indazolyl, phenyl, pyrazolopyridyl, benzisoxazolyl, pyrimidinyl, or quinolyl group, each of which optionally has at least one substituent.

Nicotinamide derivative or salt thereof

Pharmaceutical agents characterized by containing benzophenone derivatives represented by the general formula: wherein the each substituent is as defined in the specification, or salts thereof have suppressive effect on RANKL production, suppressive effect on OPG reduction and inhibitory effects on differentiation/activation of osteoclasts, and are extremely useful for treating, for example therapy and/or prevention, of various diseases in which differentiation/activation of osteoclast are involved, such as osteoporosis.

Drug containing benzophenone derivative or its salt

An object of the present invention is to provide to a compound and a pharmaceutical composition, which have excellent Syk-inhibitory activity. The present invention provides a nicotinamide derivative represented by the following formula (I) (wherein Rrepresents a halogen atom; Rrepresents a Calkyl group, a Calkenyl group, a Calkynyl group, a Ccycloalkyl group, an aryl group, an ar-Calkyl group or a heterocyclic group, each optionally having at least one substituent; Rrepresents an aryl group or a heterocyclic group each optionally having at least one substituent; and Rand Reach independently represent a hydrogen atom; and Rand Rmay form a cyclic amino group optionally having at least one substituent together with the nitrogen atom to which they bind) or a salt thereof, and a pharmaceutical composition for use in the treatment of a Syk-related disease which comprises the nicotinamide derivative or a salt thereof.

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Toyama, Japan

Mari Yamamoto