Araceli Biosciences, Inc.

Marguerite Vantangoli Policelli

Marshall Anderson

Tyler Wilson

David James Tasker

Jeffrey Alan Harris

Michael Sjaastad

David Tasker

Jeffrey Harris

Methods and systems are provided for a microscope assembly. In one example, the microscope assembly include an objective arranged at a top of a plate and aligned with a first side of the plate and a tube lens positioned below the objective along the first side of the plate and spaced away from the objective. The assembly further includes a laser auto-focus oriented parallel with a height of the plate and a light source coupled to a central region of the front face of the plate, between the tube lens and the laser auto-focus.

High throughput microscope assembly

Methods and systems are provided autofocusing an imaging system. In one example, a method includes identifying a target focal plane of a field-of-view (FOV) of each objective of the imaging system, the imaging system including two or more objectives, adjusting a vertical position of each objective relative to the target focal plane based on a light shape generated from a laser beam, and aligning a focus of each objective according to a power level detected by a sensor.

Method and systems for autofocusing

Methods and systems are provided for an imaging system. In one example, the imaging system includes a plurality of microscope assemblies arranged radially around a central axis of the imaging system, coupled to vertically oriented plates with a set of objectives arranged at tops of the plurality of microscope assemblies and wherein the plates are oriented to extend away from the central axis in a radial direction to form an x-shaped configuration.

High throughput quantitative microscopy system

Methods and systems are provided for synchronizing image capture at a multi-detector imaging system. In one example, a method includes coordinating cycling of each microscope assembly of the multi-detector imaging system through a selection of illumination channels, each microscope assembly configured to obtain an image of a portion of one of more than one microplate wells simultaneously, to generate complete images of the more than one microplate wells concurrently.

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Carver, MA, United States of America

Marguerite Vantangoli Policelli