Egis Gyogyszergyar

Egis Gyogyszergyar Rt.

Margit Csorgo

Attila Mandi

Frigyes Gorgenyi

Gyula Simig

Gabor Gigler

Gabor Blasko

Peter Tompe

Ilona Sztruhar

Jozsef Kenderfi

Csaba Szantay

Gabor Kovacs

Tibor Mezei

Zoltan Budai

Marton Fekete

Jozsef Reiter

Kalman Nagy

Pal Fekete

Imre Klebovich

Daniel Bozsing

Klara Reiter Nee Esses

Andras Egyed

Katalin Szemeredi

Lajos Novak

Eva Furdyga

Erzsebet Barczay

Eva J Tajthy Nee Juhasz

Eva Szabo

Sandor Drabant

Janos Brlik

Maria Kiraly Nee Ignacz

Klara Gado

Maria Krisztian

Antal Mosonyi

Peter Kovacs

Lidia Fedina

Peter Slegel

Margit Nagy

Sandor Erdos

Agnes Halbauer Nee Nagy

Gyorgy Pirok

Julianna Takacs Nee Bitai

Dezso Danyi

Szvetlana Zsarnoczai Nee Kurnyecova

Sarolta Benko Nee Markus

Magdolna Kenyeres Nee Feher

Gyongyi Vereczkey Nee Donath

Judit Szego

Laszlo Koncz

Zoltan Torma

Sandor Vajas

Aranka Hegedus Nee Szima

This invention relates to new oxaindene derivatives, a process for the preparation thereof and pharmaceutical compositions comprising the same. The compounds according to the invention are characterized by the general formula (1) ##STR1## wherein R.sup.1 represents lower C.sub.1-4 alkyl, lower C.sub.1-4 alkoxy or lower C.sub.3-6 cycloalkyl,

Oxaindene derivatives and process for the preparation thereof

Process for the preparation of 8 -[4 -[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7,9-d ione (buspiron) of the Formula I ##STR1## and the hydrochlorides thereof having high purity by continuously adding a solution of 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-but-2 -inyl]-8-aza-spiro[4.5]decane-7,9-dione of the formula II ##STR2## formed with an inert organic solvent having a concentration of at least 40% by weight to a suspension of a hydrogenation catalyst in an inert organic solvent and optionally converting the 8-[4-[4-(pyrimidine-2-yl)-piperazine-1-yl]-butyl]-8-aza-spiro[4.5]decane-7 ,9-dione thus obtained into the hydrochloride thereof.

Process for the preparation of high purity buspiron and the

This invention relates to a new and improved process for the preparation of 6,7-dichloro-1,5-dihydroimidazo[2,1-b]-quinazolin-2[3H]-one of formula ##STR1## (anagrelide), a valuable blood platelet antiaggregative compound. According to the process of the invention the compound of formula (I) is prepared by subjecting a new 2-cyanoiminoquinazoline derivative of the general formula ##STR2## wherein R stands for cyano or a group of the formula COOR.sup.1, in the latter R.sup.1 representing lower alkyl optionally carrying a phenyl substituent, to thermal cyclization in an acidic medium. The invention also relates to new 2-cyanoiminoquinazo-lines of the general formula (III) used for the production of anagrelide and to the preparation of the said compounds. The invention provides an advantageous process for the preparation of anagrelide which is devoid of the drawbacks of the hitherto known processes and renders possible the production of the compound of the formula (I) on industrial scale, too.

Process for the preparation of

The present invention relates to a process for the preparation of regulated release solid pharmaceutical compositions comprising 4-(2'-nitro-phenyl)-2,6-dimethyl-3,5-dimethoxycarbonyl-1,4-dihydro-pyridin e (referred to further on as 'nifedipine') as active ingredient which comprises admixing a solution or solutions of 1 part by weight of nifedipine, 0.1-1.5 parts by weight of one or more hydrophilizing agent(s) and 0.05-1.5 parts by weight of one or more retarding agent(s) formed with one or more identical or different solvent(s) completely or partly and applying the solution(s) thus obtained simultaneously or in succession onto an inert carrier, drying and sieving the product thus obtained and subsequently admixing the same with suitable conventional auxiliary agents and compressing the mixture thus obtained to tablets in a known manner and coating the tablets or filling the mixture into capsules.

Solid pharmaceutical composition and a process for preparing same

The present invention relates to an aerosol composition free of propellant gas, comprising nitroglycerin as active ingredient. The composition according to the invention is composed of:

Aerosol composition comprising nitroglycerin as active ingredient

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Budapest, Hungary

Margit Csorgo