Wisconsin Alumni Research Foundation

The Penn State Research Foundation

Margherita T Cantorna

Hector Floyd Deluca

Colleen E Hayes

Jean Humpal-Winter

Hans W Sollinger

Debra A Hullett

A method of preventing and/or treating inflammatory bowel disease, particularly ulcerative colitis and Crohn's disease, is disclosed. The method involves administering a 2-methylene-19-nor-vitamin D compound in an amount effective to treat the disease. The administration of a 2-methylene-19-nor-vitamin D compound also prevents the development of or delays the onset of inflammatory bowel disease in susceptible individuals. The preferred compounds are 1&#x3b1;-hydroxy-2-methylene-19-nor-homopregnacalciferol and 2-methylene-19-nor-20(S)-1&#x3b1;,25-dihydroxyvitamin D.

Treatment of inflammatory bowel disease with 2-methylene-19-nor-vitamin D compounds

A method of treating SLE symptoms of an SLE patient comprising administering to an SLE patient an amount of vitamin D compound effective to reduce symptoms and observing a reduction in symptoms is disclosed.

Treatment of systemic lupus erythematosis

A method of moderating transplant rejection in a transplant recipient comprising administering a dose of vitamin D compound effective to prevent transplant rejection is disclosed. Preferably, the recipient's susceptibility to opportunistic infections has not been compromised. Also preferably, the recipient has not suffered bone demineralization.

Use of vitamin D compounds to prevent transplant rejection

A method of treating arthritis symptoms induced by an infectious agent of an arthritis patient comprising administering to an arthritis patient an amount of vitamin D compound effective to reduce symptoms and observing a reduction in symptoms is disclosed.

Treatment of arthritic disease induced by infectious agents

A method of treating the multiple sclerosis symptoms of a multiple sclerosis patient is disclosed comprising administering to a multiple sclerosis patient an amount of a vitamin D compound effective to reduce symptoms and to enable an observation of a reduction in symptoms.

Growing community of inventors

Middleton, WI, United States of America

Margherita T Cantorna