Delalande S.a.

Margherita Strolin-Benedetti

Philippe L Dostert

Michel Langlois

Alain P Lacour

Patrick G Guerret

Guy R Bourgery

Jean-Francois R Ancher

Colette A Douzon

Patrice Renaut

Alain-Rene Schoofs

Jean-Francois Rumigny

A mixture of the 4 stereoisomers of formula (I) below, each of the pairs of corresponding racemic diastereoisomers and each of the enantiomers corresponding to each pair, that is to say each of said stereoisomers: ##STR1## in which R.sub.1 represents: a hydrogen atom,

5-aminoethyloxazolidin-2-one derivatives

N-arylated oxazolidine-2-one derivatives corresponding to the formula: ##STR1## and of S(+) configuration, A representing in this case the hydroxyl radical or of R (+) configuration, A designating then the N-methylamino group, as well as the acid addition salts thereof. Application in therapeutics more particularly as monoamine oxidase inhibitors.

Optically active derivatives of N-arylated oxazolidine-2-one, the

Derivatives corresponding to the general formula: ##STR1## in which Ar represents a phenyl group; a phenyl group substituted by a halogen atom or by a trifluoromethyl group; or the (chloro-3 fluoro-4) phenyl group and n is either equal to zero or equal to 1 in which case X is a chain chosen from the following: --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, --CH.sub.2 --O-- whose CH.sub.2 group is linked to Ar. These compounds are useful as medicaments more especially for the treatment of troubles of the central nervous system and senescence.

Aminomethyl-5 oxazolidinic derivatives and therapeutic use thereof

Method of treating the central nervous system troubles such as the Parkinson's disease and the senescence troubles, generally treated by the B type monoamine oxidase inhibitors, which comprises administering internally to a human being requiring such treatment a therapeutically effective amount of N-aryl 5-aminomethyl oxazolidine-2-one derivatives.

Therapeutical use of known 5-aminomethyl oxazolidine-2-one derivatives

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Paris, France

Margherita Strolin-Benedetti