University of Georgia Research Foundation, Inc.

Margaretha Wolfert

Geert-Jan Boons

Xinghai Ning

Jun Guo

Vladimir V Popik

Andrei A Poloukhtine

Therese Buskas

Sampat Ingale

Jason John Locklin

Sara V Orski

1,3-Dipole-functional compounds (e.g., azide functional compounds) can be reacted with certain alkynes in a cyclization reaction to form heterocyclic compounds. Useful alkynes (e.g., strained, cyclic alkynes) and methods of making such alkynes are also disclosed. The reaction of 1,3-dipole-functional compounds with alkynes can be used for a wide variety of applications including the immobilization of biomolecules on a substrate.

Alkynes and methods of reacting alkynes with 1,3-dipole-functional compounds

A glycolipopeptide comprising a carbohydrate component, a peptide component and a lipid component, for use as a therapeutic or prophylactic vaccine. Also provided are monoclonal and polyclonal antibodies that recognize the glycolipopeptide of the invention, as well as uses thereof.

Glycopeptide and uses thereof

Cyclic alkynes (e.g., cyclooctynes such as dibenzocyclooctynes) can be photochemically generated from cyclopropenones as disclosed herein. The cyclic alkynes can be reacted (e.g., in situ) with materials having alkyne-reactive groups (e.g., azide groups in a 'click' reaction). In preferred embodiments, the generation and reaction of the cyclic alkyne can proceed in the absence of a catalyst (e.g., Cu(I)). These reactions can be useful, for example, for the selective labeling of living cells that are metabolically modified with azido-containing surface monosaccharides, or for light-directed surface patterning.

Cyclopropenones and the photochemical generation of cyclic alkynes therefrom

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Athens, GA, United States of America

Margaretha Wolfert