Other

Gunnar Lindahl

Margaretha Stalhammar-Carlemalm

Lars Stenberg

Thomas Areschoug

Charlotte Larsson

A polypeptide is described herein which comprises (a) the sequence of SEQ ID No. 2, (b) a variant of (a) which is capable of generating a protective immune response to, or (c) a fragment of (a) or (b) of at least 6 amino acids in length which is capable of generating a protective immune response to, in the manufacture of medicament for use as a vaccine against. A pharmaceutical composition for use in vaccinating againstor Group Bcomprises a polypeptide which comprises: (A) the amino acid sequence of SEQ ID No. 2, (B) a variant of (A) which is capable of conferring protective immunity toor Group B, or (C) a fragment of (A) or (B) of at least 6 amino acids in length which is capable of conferring protective immunity toor Group B

Vaccine composition

This invention relates to a new protein, designated Rib, and subfragments, multiples or variants thereof, which confers protective immunity against infection with many group B streptococcal strains, in particular those of serotype III. The invention includes a procedure for purification of the protein, a procedure for preparation of highly specific antibodies, a reagent kit, a DNA sequence encoding the protein and a pharmaceutical composition comprising the protein or fragments or variants thereof.

Protein rib, a cell surface protein that confers immunity to many strains of the group B Streptococcus: process for purification of the protein, reagent kit and pharmaceutical composition

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Lund, Sweden

Margaretha Stalhammar-Carlemalm