Abbott Gmbh & Co Kg

Abbvie Inc.

Margaretha Bakker

Sean Colm Turner

Helmut Mack

Thomas Dale Penning

Wilfried Hornberger

Andreas Kling

Stevan Wakefield Djuric

Gerd Steiner

Udo Lange

Julie M Miyashiro

Anil Vasudevan

Karsten M Wicke

Achim Moeller

Alan Frank Gasiecki

Keith W Woods

Jyoti R Patel

Roland Grandel

Adrian Hobson

Qi Shuai

Irini Akritopoulou-Zanze

Martin Schmidt

Kathy A Sarris

Nicole Teusch

Douglas M Kalvin

Reinhold Mueller

Biqin C Li

Dawn M George

Lu Wang

Brian D Wakefield

Melissa J Michmerhuizen

Steven Lewis Swann, Jr

Vijaya J Gracias

Andrew J Long

Eric F Johnson

Peter J Kovar

Kurt Schellhaas

N St John Moore

Michael Vierling

The present invention relates to compounds of formula (I) or pharmaceutical acceptable salts, wherein A, R, R, Rand m, are defined in the description. The present invention relates also to methods of making said compounds, and compositions containing said compounds which are useful for inhibiting kinases such as Glycogen Synthase kinase 3 (GSK-3), Rho kinase (ROCK), Janus Kinases (JAK), Cdc7, AKT, PAK4, PLK, CK2, KDR, MK2, JNK1, aurora, pim 1 and nek 2.

5-substituted indazoles as kinase inhibitors

Disclosed are pyridazine compounds of the formula I which are useful for inhibiting glycogen synthase kinase 3 (GSK-3), methods of making the compounds, compositions containing the compounds, and methods of treatment using the compounds: In formula Iindicates a single bond or a double bond;

Pyridazine compounds as glycogen synthase kinase 3 inhibitors

3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof. The invention relates to 3,4-dihydrothieno[2,3-d]pyrimidin-4-one derivatives which are substituted in position 3 by 5-membered heteroaryl which may be fused to an aryl or heteroaryl radical, where the heteroaryl and, if appropriate, the fused aryl or heteroaryl radical may have 1, 2 or 3 substituents selected independently of one another from C-alkyl, C-alkoxy, C-alkylthio, halogen, CN, halo-C-alkyl, halo-C-alkoxy, hydroxy, &#x2014;NH, &#x2014;N(R6), &#x2014;NH(R6), aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl, where the substituents aryl, aryloxy, aralkyl, aralkyloxy and heteroaryl may have 1, 2 or 3 substituents selected independently of one another from C-alkyl, C-alkoxy, C-alkylthio, halogen, CN, halo-C-alkyl, halo-C-alkoxy, hydroxy, &#x2014;NH, &#x2014;N(R6)and &#x2014;NH(R6). The preparation and use of these derivatives, especially for therapeutic purposes, e.g. for the treatment of depressions, are likewise described.

3-Substituted 3,4-dihydro-thieno[2,3-d]pyrimidin-4-one derivatives, production and use thereof

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Seeheim-Jugenheim, Germany

Margaretha Bakker