Lawrence Livermore National Security, LLC

Margaret Windy McNerney

Satinderpall Singh Pannu

Carlos A Valdez

Angela C Tooker

Vanessa M Tolosa

Fang Qian

Elizabeth K Wheeler

Heeral J Sheth

Felice C Lightstone

Kris Kulp

Heather Ann Enright

Brian J Bennion

Nicholas A Be

Tuan H Nguyen

Haiyin Chen

Bryan D Hudson

Tim Carpenter

Mike Malfatti

In one embodiment, a system includes a bioreactor coupled to a substrate. The bioreactor includes: a plurality of walls defining a reservoir; a plurality of fluidic channels in at least some of the walls; a fluidic inlet in fluidic communication with the reservoir via, the fluidic channels; a fluidic outlet in fluidic communication with the reservoir via the fluidic channels; and one or more sensors coupled to the reservoir, each sensor being configured to detect one or more of: environmental conditions in the reservoir; and physiological conditions of one or more cells optionally present in the reservoir. In another embodiment, a method includes delivering media to a reservoir of a bioreactor; delivering a plurality of cells to the reservoir, controlling a reservoir temperature and a reservoir gas composition; using one or more of the sensors to monitor environmental and physiological conditions; and reporting the environmental and/or physiological conditions.

Miniaturized, automated in-vitro tissue bioreactor

Described herein are oxime compounds capable of inactivating a nerve agent, blood brain barrier (BBB)-penetration, and/or reactivation of nerve agent-inhibited acetylcholinesterase (AChE) and related methods, systems and compositions for inactivation of one or more nerve agents, therapeutic and/or prophylactic treatment of an individual, and/or decomposition of nerve agent for decontamination.

Compounds for reactivation of acetylcholinesterase and related compositions methods and systems

Growing community of inventors

Pleasanton, CA, United States of America

Margaret Windy McNerney