Synaptic Pharmaceutical Corporation

Margaret R Davis

Dhanapalan Nagarathnam

Ben E Evans

Bharat Lagu

Kanyin E Zhang

Kamlesh P Vyas

Hanumath P Kari

Donghui Cui

Michael Dunn

This invention is directed to dihydropyrimidines which are selective antagonists for human &agr; receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the &agr; receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

Dihydropyrimidines and uses thereof

This invention is directed to dihydropyrimidines which are selective antagonists for human &agr;,receptors. This invention is also related to uses of these compounds for relaxing lower urinary tract tissue, treating benign prostatic hyperplasia and for the treatment of any disease where the antagonism of the &agr;,receptor may be useful. The invention further provides a pharmaceutical composition comprising a therapeutically effective amount of the above-defined compounds and a pharmaceutically acceptable carrier.

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Redmond, WA, United States of America

Margaret R Davis