The University of Texas System

University of Washington

Mmv Medicines for Malaria Venture

Beijing University of Technology

Monash University

Glaxosmithkline Investigacion Y Desarrollo, S.l.

Margaret Phillips

Susan A Charman

Pradipsinh K Rathod

Alka Marwaha

Ramesh Gujjar

David M Floyd

David J Matthews

Aleksey I Gerasyuto

Karl Shawn Watts

Goran Krilov

Jeremy Burrows

Jose Coteron-Lopez

Michael Palmer

The present invention is related to new pyrrole derivatives in the manufacture of a medicament for preventing or treating malaria. Specifically, the present invention is related to pyrrole derivatives useful for the preparation of a pharmaceutical formulation for the inhibition of malaria parasite proliferation.

Anti-malarial agents

Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula IX: and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.

Antimalarial agents that are inhibitors of dihydroorotate dehydrogenase

Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII, and pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII: where Rthrough Rare prescribed, selectively inhibitdihydroorotate dehydrogenase. Accordingly, a method for preventing and treating malaria attaches to such compounds, as well as to pharmaceutically acceptable salts, solvates, stereoisomers, tautomers, and prodrugs thereof.

Dihydroorotate dehydrogenase inhibitors with selective anti-malarial activity

Growing community of inventors

Dallas, TX, United States of America

Margaret Phillips