University of Minnesota

Children's Hospital Medical Center

Yale University

University of Cincinnati

The United States Government

Margaret K Hostetter

Bruce Aronow

John B Harley

Kenneth Kaufman

Cheryl A Gale

Kenneth D Greis

David Andes

Kathleen S Kendrick

Julianne Vernadette Green

Alexey Porollo

Kris I Orsborn

Khoon Ghee Queenie Tan

Catherine M Bendel

Long Lu

Nian-jun Tao

Gary Dunny

Qi Cheng

Denise Devore-Carter

Lakshmi S Nandiwada

Disclosed are methods for identifying patients at increased risk of developing disseminated staphylococcal infection, which includes the steps of determining that the patient has a mutation in one or more genes selected from a MPDZ network gene, a CGNL1 network gene, a PRKRIR network gene, a MED26 network gene, a tight junction protein gene, or an immune modulator gene; and treating the patient for disseminated staphylococcal infection. Also disclosed are solid substrates and/or assays useful for carrying out the disclosed methods.

Methods and devices for bone infection treatment selection

Methods and reagents for ameliorating biofilm formation on a surface of an indwelling or implanted device in a patient resulting in decreased virulence of microorganisms such asspecies and/orspecies.

Antibody binding microbial heparin binding motif to retard or prevent microbial biofilm formation on implanted medical devices

Antibodies and agents which can bind to the propeptide of the Int1p protein of yeast microorganisms such asare provided which can be useful in methods for treating or preventing infections arising from such microorganisms. Microorganisms expressing the Int1p protein, such asand, have shown an ability to immunomodulate host cells which allows infections of these microorganisms to thrive and become virulent. The peptide regions involved in the activation of the Int1p protein are isolated and targeted so as to provide a method of disrupting activation and allow for treatment or prevention of infection by microorganisms expressing the int1p protein. In one preferred embodiment of the invention, an antibody or agent which can bind to the propeptide of the Int1p protein fromis utilized in methods to prevent or treat infections caused byor other microorganisms expressing the Int1p protein.

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An isolated and purified DNA molecule encoding Candida albicans protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.

Candida albicans gene, integrin-like protein, antibodies, and methods of use

The present invention relates to the identification and use of a family of human complement C3-degrading proteinases expressed by . The proteinase has a molecular weight of about 24 kD to about 34 kD as determined on a 10% SDS polyacrylamide gel. A preferred proteinase of this invention includes the amino acid sequence of SEQ ID NO:2.

Human complement C3-degrading protein from Streptococcus pneumoniae

An isolated and purified DNA molecule encoding protein with integrin-like motifs, the protein itself, antibodies thereto, and methods of use, are provided.

DNA encoding&mdash;candida albicans integrin-like protein

This invention relates to the identification of a human complement C3 binding protein from,and to its sequence and to methods for its purification and use. The protein binds but does not degrade or cleave C3 and is implicated in,virulence. The protein is recognized by antibodies produced by humans recovering from pneumococcal infection.

Method for isolating a C3 binding protein of streptococcus pneumoniae

Candida albicans integrin-like protein

Growing community of inventors

Milford, CT, United States of America

Margaret K Hostetter