Iomet Pharma Ltd.

Merck Sharp + Dohme Corp.

Margaret Huggett

Phillip Martin Cowley

Alan Wise

Susan Davis

Michael Kiczun

Phillip Cowley

Philip Cowley

Provided is a compound for use in medicine for inhibiting tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO), which compound comprises formula (I) wherein X, X, and X, may be the same or different and each is independently selected from C and N; X, X, X, and Xmay be the same or different and each is independently selected from C, N, O and S wherein when Xis N it has a double bond and wherein when Xis N it has a double bond; the dotted line is a bond which may be present or absent; R, R, R, R, R, R, and Rmay be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that at least one of R, R, Rand Rcomprises a group Y; and provided that the number of R, R, R, R, R, R, and Rgroups present is such that the respective valencies of X, X, X, X, X, X, and Xare maintained; and wherein Y is a group having a formula selected from (II), (III), (IV), (V) wherein L may be present or absent, and may be a substituted or unsubstituted organic linking group, and Rand Rmay be the same or different and are selected from H and a substituted or unsubstituted organic group, Xis selected from C and N, and each Rmay be the same or different and is selected from H and a substituted or unsubstituted organic group. 

Inhibitors of tryptophan-2,3-dioxygenase or indoleamine-2,3-dioxygenase

Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the following formula (I): wherein Xis selected from C and N; Xand Xmay be the same or different and each is independently selected from C, N, O and S; Y is selected from N and O; Z is selected from C, N and O; each bond represented by a dotted line may independently be a double bond or a single bond, provided that valencies at each ring atom are maintained and provided that the ring Q contains at least one double bond and provided that the atom N has a double bond; Rand Rmay be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of Rgroups present is such that the valency of Xis maintained, and the number of Rgroups present is such that the valency of Xis maintained; each Rand Rmay be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of Rand Rgroups present is such that the valency of Z is maintained; Ris selected from H and a substituted or unsubstituted organic group; Rmay be present or absent and is selected from H and a substituted or unsubstituted organic group; and Cy is a cyclic organic group. 

Pharmaceutical compound

Provided is a tryptophan-2,3-dioxygenase (TDO) and/or indoleamine-2,3-dioxygenase (IDO) inhibitor compound for use in medicine, which compound comprises the following formula: wherein X, X, X, and Xmay be the same or different and each is independently selected from C and N; X, X, X, X, X, X, and Xmay be the same or different and each is independently selected from C, N and O; each bond having a dotted line may independently be a double bond or a single bond, provided that valencies at each atom are maintained; the dotted lines joining Xwith the carbon atoms either side of Xare single bonds, and are only present when Xis absent, Xis absent and Xis C, and when these bonds are present the ring carbons on each side of Xare not directly bonded to each other; each Rmay be present or absent and may be the same or different and is selected from H and a substituted or unsubstituted organic group, provided that the number of Rgroups present is such that the valency of Xis maintained; each R, R, R, R, Rand Rmay be present or absent and may be the same or different and each is independently selected from H and a substituted or unsubstituted organic group, provided that the number of such R groups present is such that the valency of the ring carbon atoms is maintained; Rmay be present or absent and is selected from H and a substituted or unsubstituted organic group, provided that the number of Rgroups present is such that the valency of Xis maintained; each Rmay be present or absent and may be the same or different and is independently selected from H and a substituted or unsubstituted organic group, provided that the number of Rgroups present is such that the valency of Xis maintained; each R, R, R, and Rmay be present or absent and may be the same or different and is selected from H and a substituted or unsubstituted organic group, provided that the number of such R groups present is such that the valencies of X, X, X, and Xare maintained; each R, Rand Rmay be present or absent and may be the same or different and is selected from H and a substituted or unsubstituted organic group, provided that the number of such R groups present is such that the valencies of X, X, and Xare maintained; and Ris selected from H and a substituted or unsubstituted organic group, preferably H and a substituted or unsubstituted C-Calkyl group; and wherein any R group may form a ring with any other R group on an adjacent and/or proximal atom.

Growing community of inventors

Dundee, United Kingdom

Margaret Huggett