Andcare, Inc.

Other

Esa Biosciences, Inc.

Marek Wojciechowski

Robert W Henkens

John P O'Daly

Steven E Wegner

Najih Naser

Honghua Zhang

R Michael Roe

Thomas N Stewart

Deborah M Thompson

Rebecca Sundseth

Junguo Zhao

Susan E Morris

Frederick A Ebeling

Najih A Naser

Zhi-Wei Liang

Michael A Harpold

Terence M McCaffrey

An electrochemical detection system which specifically detects selected nucleic acid segments is described. The system utilizes biological probes such as nucleic acid or peptide nucleic acid probes which are complementary to and specifically hybridize with selected nucleic acid segments in order to generate a measurable current when an amperometric potential is applied. The electrochemical signal can be quantified.

Electrochemical detection of nucleic acid sequences

An apparatus is disclosed which is a microprocessor based instrument designed to conveniently and rapidly measure various analytes in environmental and biological samples. The instrument operates as a stand-alone unit powered by a battery or a DC power module and may be equipped with a communication port allowing uploading test results to a computer. Several unique electronic, microchip and software configurations were developed for the device to make it a portable, low-cost, safe, automated and simple-to-operate instrument particularly adapted for precise and accurate measurement of metal ions such as heavy metals such as lead in human blood.

Handheld electromonitor device

The present invention provides a new device for use in measuring lead levels in biological and environmental samples. Using square wave coulometry and colloidal gold particles impregnated on carbon electrodes, the present invention provides a rapid, reliable, portable and inexpensive means of detecting low lead levels. The colloidal gold modified electrodes have microelectrode array characteristics and produce significantly higher stripping detection signals for lead than are produced at bulk gold electrode surfaces. The method is effective in determining levels of lead down to at least 5 .mu.g/dL in blood samples as small as 10 .mu.L.

Colloidal-gold electrosensor measuring device

The invention relates to methods of determining micromolar levels of lead ion in various fluids, including blood. Detection of lead or other heavy metal ion concentrations as low as 1 .mu.g/dL is achieved. The methods are adaptable to the detection of low levels of lead in whole blood, employing a novel separation and release of lead ion from lead chelating agents. The disclosed methods employ isocitrate dehydrogenase-based electrodes which are particularly suited for detecting nanomolar levels of lead.

Convenient determination of trace lead in whole blood and other fluids

Growing community of inventors

Cary, NC, United States of America

Marek Wojciechowski