Lacer, S.a.

Marek W Radomski

Francisco Pubill Coy

Jose Repolles Moliner

Lydia Cabeza Llorente

Eduardo Salas Perez-Rasilla

Alicia Ferrer Siso

Marcelli Carbo Banus

Cristina Negrie Rofes

Juan Martinez Bonnin

Juan Antonio Cerda Riudavets

Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I)in which A and B independently represent any of the groups&#x2014;ONOand &#x2014;Z&#x2014;CO&#x2014;R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, or the groupin which Ris hydrogen, or an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always &#x2014;ONO, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C-Cgroup, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group

Derivatives of isosorbide mononitrate and its use as vasodilating agents with reduced tolerance

Growing community of inventors

Edmonton, Canada

Marek W Radomski