Shuntcheck, Inc.

Neuro Diagnostic Devices, Inc.

University of Pennsylvania

Children's Medical Center Corporation

Amphi Americas LLC

Aqueduct Critical Care, Inc.

Swoboda, Marek

Hochman, Matias G.

Fritz, Frederick J.

Mattiucci, Mark E.

Marek Swoboda

Frederick J Fritz

Matias Gabriel Hochman

Mark Evan Mattiucci

Michal Swoboda

Joseph R Madsen

Matias G Hochman

Mark E Mattiucci

Provided herein is a device comprising a cuirass, which includes a shell, at least one sensor, a pressure creation means for providing at least one of a negative pressure or a positive pressure within the shell, and a controller operably connected to the pressure creation means, wherein the controller is adapted to receive an input signal from the at least one sensor and adapted to provide an output signal to the pressure creation means, and wherein the pressure creation means is adapted to provide a greater or lesser amount of pressure within the shell in response to the output signal. Also provided are methods of use.

On ambulatory respiratory assist device

Systems and devices described herein provide respiration assistance to users who have difficulty breathing on their own, and include a cuirass configured to be coupled to a thorax of the user and a ventilator fluidically coupled to the cuirass. The ventilator includes a housing, a pump including an inlet and outlet, a valve, an actuator, and a controller in communication with the actuator. The controller is configured to cause the actuator to: move the valve into a first configuration in which a first flow path of the valve fluidically couples the outlet to the cuirass and a second flow path of the valve fluidically couples the inlet to an external environment during exhalation and move the valve into a second configuration in which the first flow path fluidically couples the inlet to the cuirass and the second flow path fluidically couples the outlet to the internal volume during inhalation.

Systems, devices, and methods for ambulatory respiration assistance

A system, methods and apparatus for powered monofin that propels a swimmer through water uses one of two modes of power: 1. An electric-assist mode, in which the propulsor responds to a swimmer's kick by multiplying the work of the swimmer; 2. Inverse mode, in which the propulsor deactivates when the swimmer is working. In this mode, propulsion is inversely related to the work of the swimmer. As the swimmer does more work, power from the monofin is reduced, to a predetermined, average level of propulsion. As the swimmer does less work propulsion increases to the predetermined level.

Apparatus and method for controlling fluid propulsion

An apparatus and method that utilizes thermal dilution to detect a wide range of flow rates and/or flow status in cerebrospinal fluid (CSF) shunt systems. The use of a large cold source in combination with thermosensor pad of a particular construction provide a fluid flow analyzer with the ability to detect very low levels of CSF flow. In addition, a method for adjusting thermal dilution readings to compensate for varying shunt catheter depth is shown and for determining a steady state of the thermal dilution readings. The thermosensor pad is conformable to a patient's skin contour thereby making the apparatus and method less sensitive to ambient temperature errors and, as a result, more accurate in assessing CSF flow. Furthermore, a software error check is provided for identifying poor sensor-to-skin contact for alerting an operator to re-apply the thermosensor pad to correct, as well as a post-test check to determine if temperature data is reasonable before determining flow status or flow rate.

CSF shunt flow evaluation apparatus and method using a conformable expanded dynamic range thermosensor

An implantable pressure sensor that wirelessly provides pressure data to a wireless receiver. The pressure sensor includes a first flexible membrane exposed to the region whose pressure is being monitored. In contact with this first flexible membrane is a force transducer, for measuring this pressure, that is itself suspended on an internal flexible membrane. This internal flexible membrane allows the force transducer to not only be displaced away from the first flexible membrane, but it allows for the force transducer to also be oscillated, either out-of-contact with the first flexible membrane or in-contact therewith for static/dynamic pressure sensor calibration. Another embodiment suspends an internal housing on a third flexible membrane wherein the internal flexible membrane forms the upper surface of the internal housing. An actuator for displacing/oscillating the force transducer is located within the internal housing. This permits establishing a constant distance between the force transducer and the actuator.

Pressure/force sensors having a flexible membrane, dynamic and static pressure/force sensor calibration methods

An apparatus capable of generating flow in cerebrospinal fluid (CSF) shunt systems by vibrating the shunt, tubing or shunt valve dome, or applying cyclical pressure to the various parts of the shunt system. A method of generating flow and method of using the apparatus in shunt patency assessment, for example, hydraulic resistance assessment, is also disclosed. The apparatus allows, in conjunction with a thermal dilution method or radionuclide method, a quick CSF shunt patency assessment based upon CSF shunt resistance and not upon CSF flow or intracranial pressure (ICP) separately. This provides a more objective measure of shunt obstruction compared to other methods. Furthermore, the apparatus can be used to enhance flow in shunts, identify partial occlusion before symptoms occur, differentiate between patent, partially-occluded and occluded shunts. The apparatus can be used to generate flow in shunts if there is a need to lower ICP or move drugs administered via an injection chamber or a shunt dome.

CSF shunt flow enhancer, method for generating CSF flow in shunts and assessment of partial and complete occlusion of CSF shunt systems

A method and device for testing for the presence, absence and/or rate of flow in a shunt tubing implanted under the skin by using a measurement pad having a plurality of temperature sensors, one of which is aligned with the shunt and the other sensors being symmetrically displaced on either side of the first temperature sensor in a direction transverse to the shunt tubing. These 'outer' temperature sensors act as control temperature sensors. A temperature source, e.g., a cooling agent, positioned within an insulated enclosure, is then applied at a predetermined location on the measurement pad that is insulated from the temperature sensors. The movement of this temperature 'pulse' is detected by the shunt-aligned temperature sensor via the shunt tubing as the CSF carries the temperature pulse while the control sensors detect the pulse via convection through the skin. The temperature data from these sensors are provided to a CSF analyzer that determines a CSF shunt flow status or flow rate.

Cerebrospinal fluid evaluation system having thermal flow and flow rate measurement pad using a plurality of control sensors

A system for measuring quantitative CSF flow in shunt tubing implanted under the skin. The system includes an array of thermosensors clustered in three sections, cooling device, placed on the skin surface and an associated data acquisition and analysis device. Two sensor sections are placed over the shunt on the skin and measure real time temperature responses related to CSF movement. One array placed adjacent the cooling device collects data on thermal properties of skin including skin thermal condictivity, specific heat, diffusivity, perfusion, and thermal inertia. The method involves assessing thermal properties of skin and measuring CSF flow in shunt tubing. The method is useful for shunt patency assessment, CSF valve adjustment procedures and CSF flow measurements related to CSF over drainage. Alternatively, only one section of sensors need be used when determining relative CSF flow, without the need to determine thermal skin properties and by applying the cooling device continuously.

Growing community of inventors

Philadelphia, PA, United States of America

Marek Swoboda