Sartorius Stedim Biotech Gmbh

Sartorius Stedim Data Analytics Ab

Marek Höhse

Christian Grimm

Thomas Regen

Alexander Graf

Johan Hultman

Chloe Lang

Aspects of the application relate to computer-implemented methods, process control devices, and a computer program. According to one aspect, a computer-implemented method for controlling a process in a plurality of first scale vessels via a first process control device is provided. Each of the first scale vessels contains fluid and the process is for producing a chemical, pharmaceutical, biopharmaceutical and/or biological product. The method includes controlling, by the first process control device and at least partially in parallel, the process in each of the first scale vessels. The method can include periodically determining, prior to an assigning decision and at a first frequency, first sets of process parameter values for each of the process parameters from each of the first scale vessels.

Optimized process control

Method for open-loop or closed-loop control of a process, in particular a downstream bioprocess, based on the projection of an unknown concentration of at least one substance in a sample using spectroscopy, in particular UV/vis spectroscopy, comprising the steps: Detect spectrums of a plurality of concentration samples, wherein at least two concentration samples have differing concentrations of the substance; generate several quantitative models based on the spectrums of the concentration samples, wherein the models each have a mapping of at least one spectral measurand of the spectrums to concentrations in concentration ranges, wherein the concentration ranges of two models are not identical; detect at least one sample spectrum of the sample; map the sample spectrum to at least one quantitative model of the generated quantitative models; apply the at least one quantitative model that was mapped to the sample spectrum against the sample spectrum to determine a projected value for the unknown concentration; and apply open-loop and/or closed-loop control of the process for at least one parameter based on the projected value for the undetermined concentration.

Open-loop/closed-loop process control on the basis of a spectroscopic determination of undetermined substance concentrations

One aspect relates to a bioreactor and/or mixing container that includes an outer wall and a spectroscopy cell arranged in and/or on the outer wall. The spectroscopy cell includes a first optical area and a second optical area arranged opposite the first optical area. The first optical area and the second optical area can be set at at least two different distances from one another. A specimen-receiving area is located between the first optical area and the second optical area.

Spectroscopy cell in or on an outer wall of a container and spectroscopy method

The invention relates to a bioprocess container () having an optical measuring device () for non-invasive spectroscopic measurement comprising: a container housing (), a port housing (), which is connected to the container housing () and is sealed off with respect to the interior () of the container housing (); at least one radiation-emitting element (), which is designed to transmit electromagnetic radiation through the at least one fluid contained in the container housing (); at least one radiation-receiving element (), which is designed to at least partly receive the radiation which was transmitted by the radiation-emitting element (); and at least one measuring insert (), which holds and supports the at least one radiation-emitting element () and/or the at least one radiation-receiving element ().

Growing community of inventors

Göttingen, Germany

Marek Höhse