William Marsh Rice University

Marek Buchman

Kyriacos Costa Nicolaou

Stephan Rigol

Kiran Kumar Pulukuri

Gabriel Bellavance

In one aspect, the present disclosure provides disorazole analogs of the formula: Formula (I) wherein the variables are as defined herein. In another aspect, the present disclosure also provides methods of preparing the compounds disclosed herein. In another aspect, the present disclosure also provides pharmaceutical compositions and methods of use of the compounds disclosed herein. Additionally, drug conjugates with cell targeting moieties of the compounds are also provided. 

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Marek Buchman