University of Michigan

Iowa State University Research Foundation Inc.

Wisys Technology Foundation, Inc.

Marcus T McEllistrem

Alan A DiSpirito

Jeremy David Semrau

Scott Hartsel

Jeongdae Im

Warren Gallagher

Sung-Woo Lee

Sukhwan Yoon

The present disclosures provides isolated or purified compounds, each of which bind to a metal atom. Generally, the compounds are small in size (e.g, molecular weight of less than about 1 kDa) and peptidic in nature, inasmuch as the compounds comprise amino acids. In some embodiments, the compound comprises a structure of Formula I:M-P-M-Pwherein each of Pand Pis a peptide comprising at least two amino acids, Mis a first metal binding moiety comprising a substituted imidazolone ring, Mis a second metal binding moiety comprising a substituted oxazolone ring, and wherein Mand Mbind to a single metal atom. Also provided are related complexes, conjugates, cells which synthesize the compounds of the present disclosures, substantially homogenous cultures thereof, kits and compositions, and methods of making or using the materials of the present disclosures.

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Eau Claire, WI, United States of America

Marcus T McEllistrem