Arizona State University

Mayo Foundation for Medical Education and Research

Axim Biotechnologies, Inc.

Marcus Smith

Jeffrey LaBelle

Chi Lin

Jennifer Blain Christen

David Probst

Garrett Repp

Mark Spano

Andrew Penman

Pierce Youngbar

Mackenzie Honikel

Curtiss Cook

Hongwu Jiang

The presence of analytes can be detected in the bodily fluid using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (ECS) in devices, such as handheld point-of-care devices. The devices, as well as systems and methods, utilize using Electrochemical Impedance Spectroscopy (EIS) or Electrochemical Capacitance Spectroscopy (EIS) in combination with an antibody or other target-capturing molecule on a working electrode. Imaginary impedance or phase shift, as well as background subtraction, also may be utilized.

Point-of-care apparatus and methods for analyte detections using electrochemical impedance or capacitance

Methods for detecting one or more analytes in a sample utilizing Electrochemical Impedance Spectroscopy (EIS) measurement. In one method, analyte detection includes comparing an imaginary impedance measurement to a calibration curve of concentrations for each target analyte. The calibration curve of concentrations for each target analyte is established at an optimal frequency. In another method, a signal decoupling algorithm is utilized for detection of more than one analyte on an electrode.

Analyte detection using electrochemical impedance spectroscopy-based imaginary impedance measurement

Growing community of inventors

Birmingham, AL, United States of America

Marcus Smith