Smithkline Beecham Corporation

Marcus Semones

Jerry Leroy Adams

Mui Cheung

Neil W Johnson

Stanley Dawes Chamberlain

Shinichiro Matsunaga

Domingos J Silva

Deborah Lynne Bryan

Jun Tang

Douglas McCord Sammond

Hideyuki Sato

Kristen Elizabeth Nailor

Yanhong Feng

Holly Kathleen Emerson

Yasushi Miyazaki

Yutaka Maeda

Masato Nakano

Jean-Philippe Rocher

Furo- and thienopyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such furo- and thienopyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

4-Amino-2,3-disubstituted thieno[2,3-d]pyrimidines and pharmacetical compositions thereof

Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Diamino-pyrimidines and their use as angiogenesis inhibitors

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Collegeville, PA, United States of America

Marcus Semones