Boehringer Ingelheim Vetmedica Gmbh

American Cyanamid Company

Basf Se Corporation

Marcus Rainer Knell

Guido Endert

Horst Wergen

Alexander Christ

Herbert Wachtel

Jan Hendrik Wevers

Monika Brink

Michael Aven

Benjamin Franzmann

Willi Heinz

Jonas Ruf

Guenter Krummel

Thomas Gunkel

Stefan Lehmann

Lorenz Von Harlessem

An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with an inhalation valve, which has a movable valve element, whereby the valve element is designed in an annular manner and has an outer edge and an inner edge, whereby the valve element is fastened at the outer edge, the inner edge forms the boundary of an indentation of the valve element, and the inhalation valve has a valve body seat that corresponds to the inner edge.

Inhaler

An inhaler, preferably for insertion into a nostril, in particular a horse's nostril, with a pressure generator, which has a tensioning device for the drive, and with a tensioning mechanism for tensioning the tensioning device, whereby the tensioning mechanism has a lever gear for tensioning the tensioning device.

An inhaler with a respiration indicator, whereby the inhaler has a chamber wall forming a chamber and a dispensing device for fluidic connection of the chamber to a bodily opening, preferably a nostril, whereby the respiration indicator has a wall section of the chamber wall or is formed in this way, whereby the wall section is designed to indicate a respiratory activity by deformation and/or movement.

This invention relates to an inhaler with a respiration indicator, whereby the inhaler has a chamber wall forming a chamber and a dispensing device for fluidic connection of the chamber to a bodily opening, preferably a nostril, whereby the respiration indicator has a wall section of the chamber wall or is formed in this way, whereby the wall section is designed to indicate a respiratory activity by deformation and/or movement.

Aerosol device for large animals

The invention relates to a process for the preparation of pyridylcarboxylic amides and esters I, Formula (I) wherein Hal, X and Rhave the meanings given in claim, which comprises the following steps: (a) heating a mixture consisting essentially of trichloromethylpyridine II, Formula (II), wherein Hal has the meaning given, and 1.0 to 1.5 equivalents of concentrated sulfuric acid, characterized in that the trichloromethylpyridine II in a liquid form is added to the concentrated sulfuric acid at a temperature from 110&#xb0; C. to 160&#xb0; C.; and (b) reacting the intermediate product obtained in step (a) with an amine or alcohol III, HXR, wherein X and Rhave the meaning given, optionally in the presence of a solvent and/or a base.

Process for the preparation of pyridylcarboxylic amides and esters

The invention relates to a process for the preparation of hetero)aryloxyheteroarylcarboxylic amide or ester of formula VI

Preparation of heteroarylcarboxamides

The invention relates to a process for the preparation of heteroarylcarboxylic amides and esters of formula I ##STR1## in which one or two of the groups A.sup.1, A.sup.2, A.sup.3, A.sup.4, and A.sup.5 represent a nitrogen atom and the other groups each independently represent CR.sup.3,

Preparation of hetero arylcarboxamides

A process for the preparation of dialkyl arylmalonates of formula I, ##STR1## comprises treating an arylmethlhalide of formula II ##STR2## with magnesium in an inert solvent, and a dialkyl carbonate or an alkyl chloroformate. A and R are as defined. The process is useful in the preparation of intermediate agro or pharmaceutical chemicals, or liquid crystals.

Process for the preparation arylamalonates

An effective and efficient process for the preparation of dialkyl arylmalonates of formula I, ##STR1## (ring A and R are defined in the specification). In this process, an arylmethylhalide of formula II ##STR2## is treated with magnesium in an inert solvent, the resulting Grignard reagent is treated with a dialkyl carbonate or an alkyl chloroformiate, and the resulting reaction mixture is treated with a base.

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Ingelheim, Germany

Marcus Rainer Knell