Smith + Nephew

Pall Corporation

Smith & Nephew Orthopaedics Ag

Smith Nephew Asia Pacific Pte. Limited

Smith & Nephew, Inc., Research

Marcus Lee Scott

Shilesh C Jani

Vivek Devidas Pawar

Samuel O Sowemimo-Coker

Michael B Cooper

Marc Long

Ed Margerrison

Lu Gan

Daniel A Heuer

Carolyn L Weaver

Roger Ryan Dees, Jr

Forrest A James

Matthew J Quick

Stanley Tsai

Laura S Whitsitt

There are provided herein methods and products resulting therefrom. The methods include attaching a pre-fabricated porous ingrowth structure to a substrate by applying heat, or creating and bonding an in-situ-formed porous ingrowth structure from beads on a substrate by applying heat. In some embodiments, an oxidized metal surface of the substrate is diffusion hardened during the heating process. In some embodiments, a vacuum is applied during the heating process. In some embodiments, pressure is applied during the heating process. Also provided herein are assemblies for compressing the pre-fabricated porous ingrowth structure or the beads onto the substrate during the heating process.

Methods and apparatuses for attachment of porous coatings to implants and products thereof

The present disclosure provides methods to improve the properties of a porous structure formed by a rapid manufacturing technique. Embodiments of the present disclosure increase the bonding between the micro-particleson the surface of the porous structure and the porous structure itself without substantially reduce the surface area of the micro-particles. In one aspect, embodiments of the present disclosure improves the bonding while preserving or increasing the friction of the structure against adjacent materials.

Porous structures and methods of making same

The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specific embodiments, the invention provides methods and compositions utilizing two physiological solution-processing techniques, particularly in a point of care environment, wherein centrifugation is not employed.

Preparation of a cell concentrate from a physiological solution

The present invention discloses a coating for a medical implant, wherein at least a part of said coating contains an osseointegration agent and the same and/or a different part of the coating contains an antimicrobial metal agent.

Coating and coating method

The present invention provides a coating comprising a bioactive material and an antimicrobial agent, wherein the concentration of said antimicrobial agent varies throughout the thickness of the coating.

Gradient coating for biomedical applications

A process for making a diffusion hardened medical implant having a porous surface is disclosed. The medical implant is made by a hot isostatic pressing process which simultaneously forms that porous surface and the diffusion hardened surface.

Medical implants having a porous coated surface

Method of use of a platelet/nucleated cell concentrate from bone marrow or blood to treat a bone defect

Preparation of a platelet/nucleated cell concentrate from bone marrow or blood

The present invention relates to the prevention and decrease of osteolysis produced by wear of the ultrahigh molecular weight polyethylene (UHMWPE). Methods are disclosed for the isolation of wear particles, preparation of implants exhibiting decreased wear in comparison to conventional UHMWPE and preparation of implants that cause decreased biological response in comparison to conventional UHMWPE. The implants created by these methods are also included in the present invention.

Cross-linked ultra-high molecular weight polyethylene for medical implant use

Growing community of inventors

Memphis, TN, United States of America

Marcus Lee Scott