Ear Science Institute Australia

Deakin University

Marcus Atlas

Rodney Dilley

Benjamin Allardyce

Rangam Rajkhowa

Peter Luke Santa Maria

William Brett Robertson

Robert Jeffrey Marano

Sharon Leanne Redmond

Brett Levin

Bing Mei Teh

Peter Leigh Santa Maria

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. More particularly, the invention provides for compositions and methods for preparing silk fibroin biocompatible polyurethane membranes using a solvent, which have improved biodegradation, mechanical and vibroacoustic properties.

Silk fibroin biocompatible polyurethane membranes

The present invention relates to the preparation of a membrane for use in the repair of the middle ear including perforations and damage to the tympanic membrane. The invention also provides for compositions and methods for preparing composite silk fibroin and glycerol membranes using formic acid, where the membranes have improved mechanical and vibroacoustic properties.

Silk fibroin glycerol membranes

A device for use in the repair of an ear drum in a subject in need of such treatment, said device: having a tensile strength Youngs Modulus between approximately 12.5 and 40 MPa; comprising one or more membrane layers, wherein at least one membrane layer comprises a plurality of pores; and wherein the device can support proliferation, migration and/or adhesion of cells selected from the group comprising at least any one or more of: keratinocytes, fibroblasts, vascular cells, mucosal epithelial cells, and stem cells.

Device for ear drum repair

Growing community of inventors

Subiaco, Australia

Marcus Atlas