Other

The Medical College of Wisconsin, Inc.

Iowa State University Research Foundation Inc

The University of Akron

Mcw Research Foundation, Inc.

Aix-Marseille Université

Université De Provence

Marcos Lopez

Micael J Hardy

Balaraman Kalyanaraman

Olivier Ouari

Daniel J Smith

Ming Yang Zhao

Paul Tordo

Jacek Michal Zielonka

Kathleen M Schmainda

Joy Joseph

Daniel M Alvarez

Douglas Edward Prah

Balaraman Kalyanaramn

Neil Hogg

Alain Sosa

Marisa Infante

The present invention provides mito-metformin compounds, pharmaceutical compositions thereof, and methods of using the mito-metformin compounds in the treatment of cancer.

Modified mito-metformin compounds and methods of synthesis and use thereof

Tc-labeled triphenylphosphonium contrasting agents that target the mitochondria and are useful for early detection of breast tumors using scintimammographic imaging.Tc-Mito-MAG3 possesses advantageous radiopharmaceutical properties. The uptake in the myocardium is reduced by one to two orders of magnitude compared toTc-MIBI.Tc-Mito-MAG3 exhibits fast blood clearance, with a blood half-life of less than 2 minutes in rats. A diminished myocardial uptake combined with a prompt reduction of cardiovascular blood pool signal to facilitate improved signal-to-background ratios.

99m Tc-labeled triphenylphosphonium derivative contrasting agents and molecular probes for early detection and imaging of breast tumors

A system and method for acquiring MR imaging data from a subject includes administering positively-charged nitroxides or gadolinium chelates for in vivo mitochondrial labeling, acquiring MR imaging data from the subject, and reconstructing an image of the subject having enhanced contrast in areas including metabolic and/or mitotic activity.

In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging

Methods and compositions for detecting free radicals, the compositions being spin trapping compounds comprising a nitrone having a detecting moiety and optionally having a targeting moiety for targeting the nitrone to an organ, a cell, an organelle or a molecule of interest for directly detecting free radicals, especially free radicals in biological samples.

Bifunctional and trifunctional nitrone spin trapping compounds and uses thereof

The present invention relates generally to nitric oxide releasing pharmaceutical compounds. More particularly, the present invention relates to pharmaceutical compositions that release nitric oxide under physiological conditions. In one embodiment, the present invention relates to new chemical compounds&#x2014;diazeniumdiolates nitric oxide donors&#x2014;that are based on ethambutol possessing physiological and biomedical activity.

Ethambutol based nitric oxide donors

The present invention is an inflatable, reversible life raft with a raft body including upper and lower inflatable, peripherally disposed bladders defining a closed geometric shape. The raft body also includes upper and lower inflatable masts in pneumatic communication with the upper and lower bladders, respectively. A floor closes the geometric shape between the upper and lower bladders. The upper and lower masts support upper and lower canopies, respectively. The upper canopy forms an upright, above-water enclosure to protect survivors from the elements. The lower canopy forms an underwater ballast beneath the floor of the raft, stabilizing the life raft. The reversible life raft is equipped with a reversible, collapsible ladder attached to an exterior portion of the two stacked bladders, and is equipped with two reversible ballast pouches mounted to an exterior portion of the two stacked bladders opposite the ladder. A method for establishing a reversible life raft for survivors in a body of water is also included.

Reversible life raft and method therefor

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Wauwatosa, WI, United States of America

Marcos Lopez