Massachusetts Institute of Technology

Unversität Zürich

University of Zürich

Marco Wachtel

Angela N Koehler

Shelby Doyle

Becky Leifer

Beat W Schäfer

Beat W Schaefer

Ralf Amstutz

Madeleine Henley

The present disclosure provides compounds having the general formula P-L-U, or pharmaceutically acceptable salts thereof, wherein P is a FOXO1 fusion protein binding moiety, L is a bivalent linker, and U is an ubiquitin ligase binding moiety. Also provided are pharmaceutical compositions containing such compounds and methods of using such compounds.

Small molecule binders of the oncogenic fusion transcription factor PAX3-FOXO1

This invention relates to staurosporine derivatives are effective when used in combination with ionizing radiation for the delay of progression or treatment of a proliferative disease, especially a disease associated with a PAX/FKHR translocation including a PAX3/FKHR translocation and a PAX7/FKHR translocation, more especially a solid tumor disease such as a Sarcoma, most especially an Alveolar Rhabdomyosarcoma.

Staurosporine derivatives for use in alveolar rhabdomyosarcoma

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Zürich, Switzerland

Marco Wachtel