Zambon Group S.p.a.

Sicor Inc.

Bracco International Bv

Zambon S.p.a.

Zach System S.p.a.

Zamon Group S.p.a.

Marco Villa

Maurizio Paiocchi

Alessandro Pontiroli

Nicola Diulgheroff

Claudio Giordano

Moran Pirkes

Silvia Cavicchioli

Jonathan Busolli

Antonio Nardi

Judith Aronhime

Csilla Nemethne Racz

Graziano Castaldi

Pietro Allegrini

Aldo Belli

Silvio Levi

Katiuscia Arrighi

Mauro Napoletano

Vincenzo Cannata

Laura Russo

Giuseppe Barreca

Massimo Verzini

Giorgio Soriato

Roberta Fretta

Giancarlo Grancini

Paolo Cavalleri

Andrea Nicoli

Francesco Ponzini

Dario Tentorio

Angelo Restelli

Zvi Harel

Francesco Corcella

Sergio Riva

Gaetano Marchioro

Claudio Pozzoli

Aldo Di Caterino

Alessandro Rosi

Biase Continanza

Fabio Rondina

Roberto Arosio

Racz Csilla Nemethne

Provided are crystalline forms of N-[4-[2-(2-amino-4, 7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben-zoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.

Crystalline forms of pemetrexed diacid and processes for the preparation thereof

Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]ben-zoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.

Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.

Provided are processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid, in particular, pemetrexed disodium salt, directly from pemetrexed diacid or salts thereof, i.e., without isolating the obtained pemetrexed salt prior to lyophilizing it.

Processes for the preparation of lyophilized pharmaceutically acceptable salts of pemetrexed diacid

Provided are processes for preparing intermediates of pemetrexed.

Processes for preparing intermediates of pemetrexed

The invention provides intermediates of pemetrexed of formula VI and processes for the preparation thereof. 

The present invention relates to a process for the preparation of gabapentin and, more in particular, to a method of synthesis of 1,1-cyclohexane acetic acid monoamide, an intermediate used in the preparation of gabapentin, comprising the basic hydrolysis reaction of &#x3b1;,-diaminocarbonyl-&#x3b2;,&#x3b2;-pentamethylene glutarimide.

Process for the preparation of gabapentin

A process for preparing Anastrozole is provided. In the process the steps of a. combining 3,5-bis(2-cyanoisopropyl)toluene, a solvent selected from the group consisting of acetonitrile, dichloromethane and chlorobenzene, a brominating reagent selected from a group consisting of N-bromosuccinimide and 1,3-dibromo-5,5-dimethylhydantoin, and 2,2'-azobis(2-methylpropionitrile);

Process for the preparation of anticancer drugs

A process for the nitration of conjugated alkenes of formula (I) wherein R, R1, R2, R3 and R4 have the meanings reported in the description, which allows to obtain the corresponding &#x3b2;-nitro-alkenes, characterised in that the nitrating agent is a mixture of an inorganic nitrite and iodine in the presence of an oxidising agent is described.

Process for the preparation of nitroalkenes

A process for purifying Iopamidol which uses a butanol as solvent is described. Iopamidol is obtained with high yields, also starting from aqueous solutions of the same and has characteristics in accordance with those required by pharmacopoeia.

Process for the purifying of iopamidol

A process for the preparation of heteroaryl-phenylalanines of formula (II) in which R is a hydrogen atom, a straight or branched C -C alkyl groups or a benzyl group; R is an optionally substituted 5 or 6 membered aromatic heterocyclic group with one or two heteroatoms selected among nitrogen, oxygen and sulphur; comprising a cross-coupling reaction among heteroaryl-zinc halide and phenylalanine derivatives is described. Compounds of formula (II) are intermediates useful for the preparation of compounds endowed with pharmacological activity.

Process for the preparation of heteroaryl-phenylalanines

A process of direct metalation of phenyltetrazoles useful for preparing compounds of formula (II) intermediates for the synthesis of angiotensin II antagonists is described.

Ortho-metalation process for the synthesis of 2-substituted-1-(tetrazol-5-yl)benzenes

A method for the removal of heavy metals from solutions of organic compounds by treatment with cysteine or with an N-acylcysteine is described. Organic compounds with a content of heavy metal, for example palladium, particularly low and suitable for the preparation of compounds with pharmacologic activity can be isolated from the resultant solutions.

Process for the removal of heavy metals

A compound of formula (II), wherein R,is chloro, fluoro or trifluoromethyl; R,is hydrogen, chloro, fluoro or trifluoromethyl; and R is hydrogen or a protective group for the hydroxy moiety useful as an intermediate for the synthesis of antimycotic azole compounnds.

Diol compounds as intermediates for preparing antimycotic compounds

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Marco Villa