Innovacell Gmbh

Innovacell Ag

Marco Thurner

Rainer Marksteiner

Craig Joseph Cermak

Wolfgang Schwaiger

Faheem Muhammad Asim

Eva Margreiter

The present invention relates to methods for obtaining induced smooth muscle cells (iSMCs), iSMCs, iSMCs for use in a method of treating a disease or disorder or for use in tissue engineering, and the use of skeletal muscle derived cells for obtaining iSMCs.

Methods for obtaining induced smooth muscle cells

A guidance device is provided for facilitating the placement of a puncture device (a needle) at a defined position relative to an ultrasound probe. The guidance device provides additional support of a needle tip near the needle injection site to maintain a selected path throughout an injection. The additional support is automatically retracted for simple disposal with the used syringe after an injection. The guidance device minimizes contact of soiled components and enables syringe insertion, alignment, and removal for multiple different injections without removal of an ultrasound probe from the patient. More particularly, this invention relates to a puncture device guide, comprising: an adapter configured to fixedly attach to an ultrasound probe; a syringe holder assembly configured to slidingly attach to the adapter and receive a syringe therein; wherein the syringe holder assembly is configured to slide on probe adapter in an axial direction relative to the ultrasound probe; wherein the syringe holder assembly is configured to allow for selective adjustment of a radial distance for a path of a needle of the syringe relative to the ultrasound probe; wherein the adapter includes a tip guide to selectively align a distal end of the needle with the radial distance for the path; and wherein, when the ultrasound probe is inserted into a patient, the syringe assembly is configured to slide forward on the adapter to insert the needle past the tip guide into a patient. The present invention further relates to a method of performing an injection, in particular by using a puncture device guide according to the present invention and to a guide plate configured to be used with a puncture device guide according to the present invention.

Parallel path puncture device guide and method

The present invention relates to methods for obtaining skeletal muscle derived cells (SMDC), and the use of SMDCs in a method of preventing and/or treating neuromyopathies and/or myopathies, wherein the neuromyopathy and/or myopathy is incontinence, in particular a urinary and/or an anal or fecal incontinence.

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Innsbruck, Austria

Marco Thurner