University College Cardiff Consultants Limited

K.u. Leuven Research & Development

Katholieke Universiteit Leuven

Marco Migliore

Christopher McGuigan

Jan Balzarini

A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II): wherein X is O, S, NH or CH, Y is O, S or NH, Z is O, S or CH, Ris Calkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of Rand Ris OH, and the other of Rand Ris a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety Ror Rmay be (IV): in which R, R, Rand Rare each independently H or Calkyl. In preferred embodiments, one of Ror Ris valine, leucine, isoleucine or alanine, particularly valine. 

Anti-viral pyrimidine nucleoside derivatives

A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by thevirus, said compound having the general formula (II): wherein X is O, S, NH or CH, Y is O, S or NH, Z is O, S or CH, Ris Calkyl, preferably n-alkyl, e.g., n-pentyl or n-hexyl, and one of Rand Ris OH, and the other of Rand Ris a neutral, non-polar amino acid moiety, or a pharmaceutically acceptable salt or hydrate thereof. Said neutral, non-polar amino acid moiety Ror Rmay be (IV): in which R, R, Rand Rare each independently H or Calkyl. In preferred embodiments, one of Ror Ris valine, leucine, isoleucine or alanine, particularly valine. 

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Cardiff, United Kingdom

Marco Migliore