Dompe S.p.a.

Dompe' Farmaceutici S.p.a.

Dompe Pha.r.ma S.p.a.

Marco Maria Gentile

Gaetano Clavenna

Luigi Boltri

Maria Candida Cesta

Cesare Di Palma

Antonietta Coppola

Maria Concetta Dragani

Marco Cantarini

The present invention relates to a device () for dispensing eye drops comprising a first container () containing water for injection () and a second container () containing a freeze-dried composition () comprising a drug. The first container () comprises a tubular element () with an open end portion () and the second container () comprises a wall () configured to be engaged in a fluid-tight manner around the tubular element () and a piercible barrier () which, in the assembled condition of the device (), prevents mixing of the substances contained inside the first and second containers (). The drop dispensing device () also comprises a spacer () arranged between the first and second containers (); the spacer () does not allow the tubular element () to pierce the piercible barrier ().

Dispensing device for eye drops

A process for the production of a device for dispensing eye drops. The process includes the steps of providing a first container and a second container configured to be engaged in a fluid-tight manner, providing a spacer, introducing a water-based solution inside the first container, introducing a solution or dispersion comprising a drug inside the second container, arranging the spacer between the first and second containers, engaging in a fluid-tight manner the second container and the first container, and freeze-drying the solution or dispersion comprising the drug.

Method for manufacturing a dispensing device for eye drops

The invention relates to pharmaceutical compositions of alkylammonium salts of 2-aryipropionic acids, including ketoprofen, ibuprofen, naproxen and tiaprofenic acid. The compositions are suitable for parenteral administration arid, due to buffering at pH 8 to 9, cause less pain upon injection than previously known composition.

Painless injectable compositions containing salts of 2-arylpropionic acids

A process for the co-precipitation of a substance with a stabilizer therefor, by a gas anti solvent process comprising introducing into a particle formation vessel a supercritical fluid pure or mixed with a modifier; and a solution comprising said substance and said stabilizer dissolved in a solvent; so as said solvent is extracted from the solution by said supercritical fluid and co-precipitation of the substance and stabilizer occurs. The process may be carried out using an apparatus, for example, shown in FIG., comprising a particle formation vessel () and a nozzle () having a central orifice () serving to introduce a solution of the substance and a plurality of outer orifices () serving to carry a flow of supercritical fluid into the particle formation vessel (), such that the solvent is extracted from the solution by the supercritical fluid and precipitation of micron sized particles of the substance/stabilizer occurs.

Supercritical fluids processing: preparation of protein microparticles and their stablilisation

Parenteral pharmaceutical compositions containing ammoniomalkyl salts of

The present invention relates to a topical formulation of gel-like consistency, but nebulizable by a mechanical pump, containing colloidal silices as gelifying agent.

Growing community of inventors

L'Aquila, Italy

Marco Maria Gentile