Aptalis Pharma Limited

Allergan Pharmaceuticals International Limited

Eurand Pharmaceuticals, Ltd.

Eurand Italia S.p.a.

Marco Marconi

Luigi Giovanni Mapelli

Giovanni Ortenzi

Massimo Maria Calanchi

Leonardo Gentilini

Epx European Pat Off

Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of coated particles, each of which is comprised of a core coated with an enteric coating comprising at least one enteric polymer and 4-10% of at least one alkalinizing agent, or have moisture contents of about 3% or less, water activities of about 0.6 or less, or exhibit a loss of activity of no more than about 15% after six months of accelerated stability testing.

Stable digestive enzyme compositions

Methods of producing stable pancreatic enzyme compositions

Stable pancreatic enzyme compositions

The invention relates to a method by which it is possible to prepare a formulation consisting of thickening or suspending agents and other excipients, having the property of dispersing and dissolving quickly in water or aqueous vehicles, without clot formation, with which it is possible to prepare an extermoraneous homogeneous suspension of solid particles and more particularly of micro-encapsulated drugs, which otherwise have the tendency to precipitate or float.

Formulation for preparing extemporaneous homogeneous microcapsule

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Cinisello Balsamo, Italy

Marco Marconi