Inalco S.p.a.

Ritter Pharmaceuticals, Inc.

Inalco S.r.l.

Marco Manoni

Giovanni Cipolletti

Luana Vagnoli

Jacopo Chini

Silvia Giacomelli

Liana Salsini

Silvia Biagiolini

Debora Bartalucci

Giancarlo Tamerlani

Ilaria Lombardi

Sandro Miletti

Andrea Danesi

Rosanna Abbate

Maria Anna Gori

The present invention describes a process for preparing ultrapure (&#x2265;95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involvingand

Process for the production of ultrapure galacto-oligosaccharides

The present invention describes a process for preparing ultrapure (&#x2267;95%) galacto-oligosaccharides (GOS), starting from GOS at lower purities by using sequential microbiological purifications involvingand

The present invention relates to a process of synthesis of &#x3b1;-sialyl oligosaccharides and in particular of 6'-sialyllactose and its salts comprising a step of coupling by Koenigs-Knorr reaction under conditions that allow its use on an industrial scale.

6'-sialyllactose salts and process for their synthesis and for the synthesis of other alpha-sialyloligosaccharides

The present invention relates to a process for industrially producing tagatose starting from galactose and provides for chemical isomerisation in presence of XAlOand XOH (with X=Na, K) and microbiological purification of the residual galactose.

Tagatose preparation

The present invention relates to a process for the preparation of sulphated glycosaminoglycans derived from N&#x2014; acetylheparosan which comprises: a) N-deacetylation and N-sulphation of the N-acetylheparosan polysaccharide prepared from natural or recombinant bacterial strain, preferably K5, b) enzymatic epimerization with the glucuronyl C5-epimerase enzyme, c) partial O-sulphation followed by a partial O-desulphation, d) partial 6-O-sulphation, e) N-sulphation and an intermediate step of controlled depolimerization characterised by the fact that both O-sulphations (O-sulphation and 6O-sulphation) are partial. Furthermore the invention relates to the products obtained according to the process which show a ratio between the anti-Xa activity and anti-IIa activity equal to or higher than 1 and to compositions comprising said products in combination with suitable and pharmaceutically acceptable excipients and/or diluent.

Polysaccharide derivatives with high antithrombotic activity in plasma

The present invention refers to the preparation of O-sulphated, N-sulphatated or N-acetylated derivatives, both epimerised or non epimerised, of K5, K4, and optionally defructosilated K4 and K40 polysaccharides and to their use as antiinflammatory agents in chronic and acute inflammations.

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Vinci, Italy

Marco Manoni