Sartorius Stedim Biotech Gmbh

Levitronix Gmbh

Marco Leupold

Simon Topp-Manske

Christian Grimm

Bernward Husemann

Wei Gao

Stefan Schlack

Bjoern Nickel

Thomas Nussbaumer

Thomas Holenstein

Jochen Scholz

Lars Böttcher

Andreas Prediger

Robin Heese

Bjorn Nickel

Sina Götemann

System for detecting at least one presence of foam of a medium in a bioreactor plant, wherein the system comprises: —a bioreactor plant having at least one disposable container for receiving the medium that may comprise the foam; and—at least two capacitive sensor units which are attached at at least two different situating positions of the bioreactor plant, wherein the capacitive sensor units each comprise at least one electrode system for capacitive measurement and are able to detect the presence of foam at the at least two situating positions on the basis of the capacitive measurement; and wherein the capacitive sensor units are designed to transmit captured data relating to the presence of foam to at least one monitoring unit for monitoring, open-loop and/or closed-loop control of foam formation in the bioreactor plant on the basis of said data.

Detecting foam in a bioreactor plant

A mixing device having a stirring element can include: a container for receiving fluids and/or solids; and at least one rotatable stirring element for mixing the fluids and/or solids; wherein the stirring element comprises a first bearing element and a second bearing element which are arranged at or near opposite ends of the stirring element; wherein the first bearing element is mounted on a first face of the container and the second bearing element is mounted on an opposite second face of the container; wherein the first bearing element comprises at least one non-permanently magnetized element such that it can be moved in rotation by externally induced reluctance forces, and wherein the second bearing element is mounted in a contactless manner by externally induced magnetic forces.

Mixing device having a stirring element

A container () of a bioreactor (a,) has a container interior () designed for being filled with a medium () including a photoreactive material, and designed for at least partially triggering a photochemical reaction of the photoreactive material. The container () has at least one illuminant receiving pouch () that is at least partially transparent for an electromagnetic radiation (), and that is arranged on a illuminant opening () within the container interior () and is designed to receive at least one illuminant () from an outer side (A) through the illuminant opening (). The illuminant at least partially irradiates the medium () such that the photochemical reaction of the photoreactive material can be triggered by electromagnetic radiation () emitted by the illuminant and the illuminant is isolated in relation to the medium () by the illuminant receiving pouch ().

Illumination for a photobioreactor

A bioreactor () includes a receiving container () for receiving a disposable bag (). A bottom surface () of the receiving container () is designed to support the disposable bag () in the receiving container (). An outlet opening () is formed in the bottom surface () and tapers down with respect to the ground for receiving a drain port () of the disposable bag (). The drain port is complementary to the outlet opening ().

Bioreactor system and method

A sterile packaging unit includes a disposable bioprocessing component () and a packaging (). The disposable bioprocessing component () has a component wall that encloses a processing space and on which is secured a sensor system () with at least one sensor head (T, P, I, L, D) and with attached sensor electronics () that include a memory unit (). The packaging () hermetically encloses the disposable bioprocessing component () and has a flexible packaging wall. The disposable bioprocessing component () and the packaging (). are sterilized by being jointly irradiated with ionizing radiation. The sensor electronics () are connected electrically to a contact unit () extending through the packaging wall.

Sterile packaging unit and method for producing same

A single use probe, sterilizable by irradiation, for a single use component for use in a biopharmaceutical process, comprises at least one sensor relevant for the biopharmaceutical process, an RFID tag and a memory rewritable in principle, in which data with respect to an integrity check of the single use probe are stored. A method for quality assurance of such a single use probe comprises: providing the probe with an RFID tag and a memory rewritable in principle, in particular a FeRAM memory as part of the RFID tag; defining a measurement-principle-specific quality parameter of the single use probe; defining a tolerance value for the parameter; performing an integrity check of the probe by first determining and writing into the memory values of the defined quality parameter before sterilization of the probe by irradiation; determining the values of the defined quality parameter after irradiation; and comparing the values of the quality parameter determined before radiation to those determined after.

Single use probe sterilizable by irradiation and method for the quality assurance of a single use probe

A system for receiving a disposable bag () has a receiving container () with a container interior for receiving the disposable bag () and a temperature-control hollow wall () that at least partially surrounds the container interior of the receiving container (). A temperature-control unit controls the temperature of the container interior by will a temperature-control medium arranged in the temperature-control hollow wall () at a maximum pressure of about 1 bar.

System, device and method for receiving a disposable bag

A sterile packaging unit includes a disposable bioprocessing component () and a packaging (). The disposable bioprocessing component () has a component wall that encloses a processing space and on which is secured a sensor system () with at least one sensor head (T, P, I, L, D) and with attached sensor electronics () that include a memory unit (). The packaging () hermetically encloses the disposable bioprocessing component () and has a flexible packaging wall. The disposable bioprocessing component () and the packaging () are sterilized by being jointly irradiated with ionizing radiation. The sensor electronics () are connected electrically to a contact unit () extending through the packaging wall.

Growing community of inventors

Kassel, Germany

Marco Leupold