Omeros Corporation

Marco Jonas

Jennifer Lynn Gage

Thomas L Little, Jr

Wayne Douglas Luke

Neil S Cutshall

Karl Reineke

Elisabeth C A Brot

Michael James McDermott

Thomas L Little

Michael James Mcdermott

Jennifer Leigh Nelson

Ekaterina Albert

Christopher Scott Seadeek

Xufeng Sun

Suba Iyer

Elisabeth CA Brot

Karl E Reineke

The invention relates to a novel variable hydrate crystalline form of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, methods for the preparation thereof, pharmaceutical compositions thereof and their use in the inhibition of PDE10.

Solid state forms of a PDE10 inhibitor

The present invention is directed to an improved process for the preparation of compounds of Formula (II) and Formula (III), which are useful in the inhibition of PDE10. In particular, the present invention is directed to an improved process for the preparation of 1-(5-(4-chloro-3,5-dimethoxyphenyl)furan-2-yl)-2-ethoxy-2-(4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl)ethanone, which is useful in the inhibition of PDE10.

Processes and intermediates for the preparation of a PDE10 inhibitor

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Cohoes, NY, United States of America

Marco Jonas