Avl Medical Instruments Ag

Roche Diagnostics Operations, Inc.

Avl Ag

Marco J Leiner

Otto S Wolfbeis

Tobias Werner

Andrei Boila-Gockel

Werner E Ziegler

Huarui He

Ingo Klimant

Christian Huber

Jorg Daub

Max Lippitsch

Dietmar Werkl

Stefan Heinl

Matthias Kollmannsberger

Thomas Gareis

Ute Kosch

Léonie Weis

Hermann J Marsoner

Helmut List

Erich Kleinhappl

Hellfried Karpf

Karl Harnoncourt

Gerald Kirchmayer

Sonja Draxler

Leonie Weiss

A process for producing a film of a hydrophilic polymer on the inner surfaces of a fluidic component is provided comprising subjecting the inner surfaces of the fluidic component to a physicochemical pre-treatment, contacting the inner surfaces of the fluidic component with a solution of the hydrophilic polymer, replacing the solution of the hydrophilic polymer with a gaseous medium in such a manner that firstly the inner surfaces of the fluidic component remain wetted with part of the polymer solution, and removing the solvent to produce a film of the hydrophilic polymer on the inner surfaces of the fluidic component. The hydrophilic polymer used has a surface wettability for aqueous solutions which is higher than the surface wettability of the inner surfaces of the fluidic component itself.

Process for hydrophilizing surfaces of fluidic components and systems

An electrochemical gas sensor is provided comprising a gas-permeable and substantially ion- and liquid-impermeable membrane for separating an aqueous outer solution and an inner electrolyte solution comprising a gas-permeable film of a hydrophilic polymer consisting essentially of non-covalently cross-linked polymer chains, wherein the film is present directly at least on the side of the membrane facing the aqueous outer solution, which has a surface wettability for the aqueous outer solution that is higher than the surface wettability of the membrane for the aqueous outer solution.

Electrochemical gas sensor with a hydrophilic membrane coating

The invention relates to a method of determining an alkali ion in a sample, wherein the alkali ion is contacted with a compound having a luminophoric moiety and an ionophoric moiety, which ionophoric moiety reacts with the alkali ion present in the sample, wherein the luminophoric moiety changes its luminescence properties, after which the luminescence is measured and the alkali ion determined utilizing the test reading, which method is characterized in that the compound utilized is a diaza-cryptand of the general Formula I: ##STR1## in which X is the luminophoric moiety, m is the number 0, 1 or 2, and o and p independently mean the numbers 0, 1 or 2.

Method of determining an alkali ion

In a sensor layer for quantitative determination of at least one chemical component in a gaseous or liquid sample medium containing a chromophore which is directly or indirectly responsive to the component being determined by changing its absorption spectrum, and a luminophore which is not responsive to the component being determined, where there is an at least partial overlap between the emission spectrum of the luminophore and the absorption spectrum of the chromophore, and where the energy transfer between luminophore and chromophore produces a measurable change in at least one luminescence characteristic of the luminophore, the luminophore L and the chromophore .GAMMA. are ionic substances with differing electrical charges, which are incorporated in a matrix material that is permeable to the chemical component being determined.

Luminescence-optical method and sensor layer for quantitative

The invention relates to a compound having the general Formula I in which one of the groups R.sub.1,R.sub.2,R.sub.3,R.sub.4,R.sub.5,R.sub.6 and R.sub.7 represents an ionophoric moiety and the remaining groups each independently are hydrogen, a lipophilic or hydrophilic group or a reactive group for coupling to a polymer or a biomolecule, or R.sub.2 forms an aromatic ring system together with R.sub.3 and R.sub.5 forms an aromatic ring system together with R.sub.6. the compound of the invention is useful as a luminescence indicator for cations.

Luminescence indicator including ionophoric moiety

The invention relates to a compound having the general Formula I ##STR1## in which one of the groups R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 represents an ionophoric moiety and the remaining groups each independently are hydrogen, a lipophilic or hydrophilic group or a reactive group for coupling to a polymer or a biomolecule, or R.sub.2 forms an aromatic ring system together with R.sub.3 and R.sub.5 forms an aromatic ring system together with R.sub.6. The compound of the invention is useful as a luminescence indicator for alkali ions.

Luminescence indicator

The invention relates to a method of determining an alkali ion in a sample, wherein the alkali ion is contacted with a compound having a luminophoric moiety and an ionophoric moiety, which ionophoric moiety reacts with the alkali ion present in the sample, wherein the luminophoric moiety changes its luminescence properties, after which the luminescence is measured and the alkali ion determined utilizing the test reading,

In a method for calibration of a pH measuring element whose ion-permeable, hydrophilic polymer layer is brought into contact with an aqueous solution prior to calibration, the aqueous solution is displaced or replaced by a gaseous calibrating medium, and residues of the aqueous solution remaining in the ion-permeable polymer layer. The gaseous calibrating medium contains a known amount of at least one component which is acid or basic in aqueous solution which reacts with the remaining residues of the aqueous solution in the polymer layer, such that a defined pH value is established in the polymer layer, which is employed for calibration of the measuring element.

Method for calibration of a pH measuring element

In a device for determining the concentration of a reagent from a group consisting of gases with acid or alkaline reaction in aqueous environments, and volatile acids and bases in liquid or gaseous samples, a sample chamber is situated in a housing and a unit for pH measurement with a reaction space is separated from the sample chamber by an ion-impermeable, gas-permeable membrane. The feeding of the reaction space with buffer solution is facilitated by connecting the reaction space by means of an ion-permeable channel to a reservoir for a buffer solution located outside of the pH measuring unit.

Analyzing device including an ion-permeable channel connecting a sample

A luminescence-optical indicator for determining the activity of alkali metals based on decay time includes at least three components that are chemically bound to one another, i.e., a fluorophor, a functional group with which the luminescence decay time of the fluorophor can be influenced, and a ionophor binding the alkali metal ions to be measured in a selective and reversible manner, the effect of the functional group on the decay time of the fluorophor being altered in dependence on the activity of the alkali metal ions.

Luminescence-optical indicator for determining the activity of alkali

Substance of an optical fluorescence measuring arrangement for measuring

A method for the quantitative determination of one or more chemical parameters of a sample medium employs a fluorescent agent which is not responsive to the parameter to be determined and which has an excitation spectrum and an emission spectrum, and a closely adjacent chromogenic agent which responds to the parameter of the sample medium to be determined by a change in its absorption spectrum the emission spectrum of the fluorescent agent at least partically overlapping the absorption spectrum of the chromogenic agent. The absorption maximum of chromogenic agent is shifted in accordance with the parameter to be determined, causing a reduction of fluorescence decay time t in the fluorescent agent, thereby enabling quantitative determination of the chemical parameter with improved long-term stability and infrequent calibrations.

Method for quantitative determination of at least one chemical parameter

In order to improve the response behavior of an optical sensor for determining at least one parameter in a liquid or gaseous sample, the sensor including a substrate which is provided with carrier particles and a fluorescent indicator immobilized thereon, the substrate is configured as a polymer film transparent to both excitation and emission radiation, and the individual carrier particles carrying the fluorescent indicator in immobilized form are bonded with only part of their surface to a thin layer of a thermoplastic material adhering to the polymer film and assume thermosetting properties after the carrier particles have been pressed in, whereas the other part of the surface of the carrier particles extend into an optically transparent hydrogel layer which covers the thermoplastic layer and in which the carrier particles are anchored mechanically. Such sensors may easily be attached to the end of an optical waveguide and may be made in any size by a simple punching operation.

Optical sensor for determining at least one parameter in a liquid or

In order to improve a one-way measuring element, which may be inserted into an analyzer for analyzing gaseous or liquid samples and which comprises a measuring channel with a measuring zone and one or more sensors located therein, the proposal is put forward that the one-way measuring element be provided with a sensor part whose measuring channel has seals on both ends, and with a sample-taking part, and that a coupling element be placed at the inlet end of the measuring channel for direct coupling of the sample-taking part containing the gaseous or liquid sample, and that the measuring channel be filled with a calibrating and storage medium prior to the measuring process, and that the calibrating and storage medium contained in the measuring channel be displaced by the sample flowing in after the sample-taking part has been coupled to the sensor part. The one-way measuring elements obtained in this way are characterized by great simplicity of design and ease of handling.

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Graz, Austria

Marco J Leiner