Ambrx, Inc.

Mitsubishi Tanabe Pharma Corporation

Mitsubishi Tanabe Pharma Corporat

Marco Gymnopoulos

Feng Tian

Ryo Fujita

Ying Sun

Nick Knudsen

Roland A Newman

Anna-Maria A Hays Putnam

Richard Spence Barnett

Andrew Beck

Julia Coronella

Anjuli Timmer

Vincent Blot

Harun Rashid

Presented herein are novel monoclonal cMET binding agents that are conjugated to pyrrolobenzodiazepine toxins, composition thereof and uses thereof for the treatment of cancer.

Drug conjugates of cMET monoclonal binding agents, and uses thereof

Described herein are novel anti-CD3 antibodies conjugated to folate and uses thereof treatment of diseases or conditions that would benefit from such conjugate are provided.

Anti-CD3-folate conjugates and their uses

Presented herein, in certain embodiments, are compositions comprising monoclonal binding agents that specifically bind to the extracellular domain of cMET and uses thereof.

CMET monoclonal binding agents, drug conjugates thereof and uses thereof

This invention relates to prostate-specific membrane antigen (PSMA) antibodies and antibody drug conjugates comprising at least one non-naturally-encoded amino acid. Disclosed herein are &#x3b1;PSMA antibodies with one or more non-naturally encoded amino acids and further disclosed are antibody drug conjugates wherein the &#x3b1;PSMA antibodies of the invention are conjugated to one or more toxins. Also disclosed herein are non-natural amino acid dolastatin analogs that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such dolastatin analogs. Typically, the modified dolastatin analogs include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid antibody drug conjugates, dolastatin analogs, and modified non-natural amino acid dolastatin analogs, including therapeutic, diagnostic, and other biotechnology uses.

Prostate-specific membrane antigen antibody drug conjugates

Growing community of inventors

San Diego, CA, United States of America

Marco Gymnopoulos