Dna Sciences Laboratories, Inc.

Genaissance Pharmaceuticals, Inc.

Duke University

Marco Guida

Jeff Hall

Jeffrey R Marks

William P Petros

Oliver M Colvin

Janice Kurth

James J Vredenburgh

Jay B Lichter

Methods for detecting variant genes having a polymorphism associated with reduced metabolism of a substrate selected from the group consisting of a CYP3A4 substrate, a CYP3A5 substrate and a GSTM1 substrate in an individual are disclosed. The methods are genotyping methods to identify specific polymorphisms which have been found to be associated with reduced metabolism of chemotherapeutic agents, such as cyclophosphamide and BCNU. Also disclosed are novel polymorphic nucleic acid molecules useful in the methods of the invention.

Methods for evaluating the ability to metabolize pharmaceuticals

Disclosed are novel polymorphisms in the human cytochrome P450 2A6 gene and the use of those polymorphisms as predictive sequences for altered metabolism or occurrence of disease.

Genetic typing of the human cytochrome P450 2A6 gene and related methods

Genetic typing of the human cytochrome P450 2A6 gene and related materials and methods

Genetic polymorphisms are identified in the human STP2 gene that alter STP2-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for STP2 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

Genotyping the human phenol sulfotransferbase 2 gene STP2

Genetic polymorphisms are identified in the human CYP3A4 gene that alter CYP3A4-dependent drug metabolism. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for CYP3A4 substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.

Isolated CYP3A4 nucleic acid molecules and detection methods

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San Diego, CA, United States of America

Marco Guida