Università Degli Studi Di Trento

Protera S.r.l.

Università Degli Studi Di Firenze

Universitá Degli Studi Di Siena

Consorzio Interuniversitario Nazionale Per La Scienza E Tecnologia Dei Materiali

Marco Fragai

Claudio Luchinat

Leonardo Manzoni

Pierfausto Seneci

Cristina Nativi

Ivano Bertini

Alessandro Provenzani

Vito Giuseppe D'Agostino

Natthakan Thongon

Chiara Zucal

Preet Lal

Valentina Adami

Luciana Marinelli

Ettore Novellino

Linda Cerofolini

Carmelo Fuccio

Mauro Lo Conte

Chiara Venturi

Object of the present invention are new aza-tanshinone derivatives, a method for their preparation and their use in therapy, particularly, but not limited to, as anti-tumor agents and anti-inflammatories. The invention comprises also the pharmaceutical compositions containing them.

Aza-tanshinone derivatives, process for their preparation and their use in therapy

Described herein are derivatives of arylsulfonamido-substituted hydroxamic acid of formula (I) having good solubility in water and inhibitory activity of matrix metalloproteinases, useful for the preparation of pharmaceutical compositions for the treatment of diseases associated to a pathologic activity and/or an over-expression of metalloproteinases, and of cosmetic preparations having anti-ageing properties in particular for hair and skin. 

Derivatives of arylsulfonamido-substituted hydroxamic acid as matrix metalloproteinases inhibitors

Growing community of inventors

Sesto Fiorentino, Italy

Marco Fragai