Dobfar S.p.a.

Acs Dobfar S.p.a.

Antibiotici Cristallizzati Sterili S.r.l.

Marco Falciani

Renato Broggi

Leonardo Marsili

Sergio Dusci

Roberto Bonamigo

A bag for preserving and transporting a sterile product in powder form and a method for preparing solutions of the sterile product in the bag. The bag contains a sterile product in powder form and has a port closed by a membrane through which a solvent can be fed into the bag to form a sterile solution of the powder. Further, the bag contains an amount of the sterile product in powder form adapted to give with the solvent and within the bag a reconstituted ready to use solution that only partially fills a capacity of the bag.

Bag for preserving and transporting sterile products in powder form and for forming solutions of said products in the bag

The invention concerns a method for the treatment of tumors sensitive to Paclitaxel, by intra-arterial injections of dispersions of microparticles of albumin incorporating Paclitaxel in physiological solutions.

Method for the treatment of solid tumors by albumin microparticles incorporating paclitaxel

The present invention relates to a composite container suitable for the lasting preservation, under absolutely sterile conditions, of sterile, solid products, particularly pharmaceutical products. Such a container comprises an inner bag, or tubular element, made of low-density polyethylene and directly containing the product to be preserved and an outer bag consisting of three layers of different materials, of which polyethylene, the high-density type being preferred, or polyvinylchloride forms the innermost layer, aluminium the intermediate layer and a polyester resin the outermost one: the ends of the bags are hermetically sealed.

Composite container for sterile solid products

There are provided 3-azinomethyl rifamycins of the formula I: ##STR1## wherein R represents hydrogen or acetyl;

3-azinomethyl rifamycins

Cephapirine esters having the formula ##STR1## wherein R is selected from the group consisting of ##STR2## Such esters and salts thereof, having antibiotic activity, are prepared by reacting 7-ACA with bromophtalide or chloromethylpivalate in the presence of an alkylamine, at a temperature in the range of 0.degree.-70.degree. C. The reaction compound is reacted with chlorohydrate chloride of 4-piridylthioacetic acid. A salt of the compound of formula (I) is isolated from the reaction mixture, after washing with acidic water and addition of a pharmaceutically acceptable acid, by treatment with a suitable solvent.

Cephapirine esters and salts thereof

Cephalosporine desacetoxy esters having the formula ##STR1## wherein R is selected from the group consisting of ##STR2## and R.sub.1 is selected from the group consisting of ##STR3## Such esters and salts thereof having antibiotic activity are prepared by reacting 7-ADCA with bromophthalide or chloromethyl pivalate in the presence of an alkylamine at a temperature in the range of 0.degree.-70.degree. C. The reaction product is reacted with chloride chlorohydrate of D(-)dihydrophenylglycine or D(-)p-hydroxy phenylgycine. A salt of the compound of formula (I) is isolated from the reaction mixture, which after washing with acidic water and addition of a pharmaceutically acceptable acid is obtained by treatment with suitable solvent.

Cephalosporine desacetoxy esters and salts thereof

N-carboxy cefadroxil disodium salt having formula ##STR1## Said salt is endowed with antibiotic activity and can be administered parenterally.

N-Carboxy cefadroxil sodium salt

Salts of cefadroxil with an amino acid selected from the group consisting of L-lysine, L-arginine and acetylcysteine. Said salts are obtained by reacting an aqueous suspension of cefadroxil with an aqueous solution of an amino acid or its derivative, selected from the group consisting of L-lysine, L-arginine and acetylcysteine. To isolate the salt, the aqueous solution is submitted to lyophilization.

Cefadroxil acetylcysteinate salt

Process for the production of 6-D-.alpha.-amino-p-hydroxyphenylacetamido penicillanic acid which is a potent antibiotic also known generically as amoxicillin. According to the process there is reacted a boron derivative of 6-APA with an acylating agent derived from the D(-)-p-hydroxyphenylglycine, in dimethylformamide or in dimethylsulfoxide in admixture with methylene chloride or chloroform, hydrolyzing and then removing the enaminic group.

Process for the production of 6-D-.alpha.-amino-p-hydroxyphenylacetamido

Process for preparing cephalexine monohydrate and cephadroxyl monohydrate, according to which a reaction is carried out of a mixed anhydride prepared from a Dane salt of phenylglycine or p-hydroxyphenyl-glycine with a chloroformiate, with an aqueous solution of 7-ADCA in a solvent selected from the group comprising dimethyl sulphoxide, dimethylacetamide, formamide, dimethylformamide and dioxane.

Process for preparing derivatives of 7-amino-desacetoxy cephalosporanic

A process for preparing cephalosporines in which a cephalosporanic derivative is treated with a polar solvent, then with an organic base to give a mixture which is cooled at a temperature lower than -25.degree. C. A cyclic derivative of boron is added to the mixture and the temperature is increased to about 0.degree. C. An intermediate compound is formed which by treatment first with an acylating agent and then with a mixture of water and alcohol provides a solution containing cephalosporines.

Process for preparing cephalosporines

A process for preparing penicillins, in which 6APA is treated with a polar solvent, then with an organic base to give a mixture which is cooled at a temperature lower than -25.degree. C. A cyclic derivative of boron is added to the mixture and the temperature is increased to about 0.degree. C. An intermediate compound is formed which by treatment first with an acylating agent and then with a mixture of water and alcohol provides a solution containing the penicillin.

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Milan, Italy

Marco Falciani