Fondazione Istituto Italiano Di Tecnologia

University of California

Alma Mater Studiorum-Universitá Di Bologna

Universitá Degli Studi Di Padova

Fondazione Istituto Italiano Di Technologia

Forschungszentrum Julich Gmbh

Scuola Internazionale Superiore Di Studi Avanzati - Sissa

Marco De Vivo

Jose Antonio Ortega Martinez

Daniele Piomelli

Anand Ganesan

Sohail Jahid

Jose Manuel Arencibia Jimenez

Claudia Sissi

Rita Scarpelli

Daniela Pizzirani

Anders Bach

Andrea Cavalli

Chiara Pagliuca

Marco Migliore

Natalia Realini

Angelo Danilo Favia

Damien Habrant

Giuseppe Legname

Jose Antonio Ortego Martinez

Anna Minarini

Paolo Carloni

Angelo Favia

Silvia Vanni

Jose Antonio Ortega MARTÍNEZ

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.

Substituted 1,3,5-triazines as inhibitors for a rho family of GTP-ases

The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof:  It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses, in particular in the treatment of diseases or disorders associated to increased relative to physiological or desired RhoJ/Cdc42 levels of expression or function.

Substituted pyrimidines as inhibitors for a Rho family of GTP-ases

The invention relates to a class of 5-carboxamide-2-thiobarbituric acid derivatives which inhibits human type II topoisomerase (topoII) enzyme and to use thereof as medicaments especially for blocking the proliferation of cancer cells and treating cancer. The invention also provides a method for the manufacture of the 5-carboxamide-2-thiobarbituric acid derivatives.

5-carboxamide-2-thiobarbituric acids and use thereof as medicaments

The present invention concerns 4-amino-2-pyrido-bicyclic pyrimidines of Formula (I) that function as type II topoisomerase inhibitors and their use thereof as medicaments especially in the treatment of cancer. The invention also provides a method for the manufacture of 4-amino-2-pyrido bicyclic pyrimidines of Formula (I).

4-amino-2-pyrido-bicyclic pyrimidines and use thereof as topoisomerase II inhibitors

The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.

Benzoxazolone derivatives as acid ceramidase inhibitors, and their use as medicaments

Multitarget inhibitors of the enzymes Fatty Acid Amide Hydrolase (FAAH), Cyclooxygenase-1 (COX-1) and/or Cyclooxygenase-2 (COX-2) having a specific carbamate moiety on the meta or ortho position of the A ring of a substituted biphenyl core and having an halogen in the ortho position of the B ring of the biphenyl core. Also concerns the therapeutical application of the multitarget inhibitors, in particular, in the prevention and treatment of cancer.

Multitarget FAAH and COX inhibitors and therapeutical uses thereof

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Genoa, Italy

Marco De Vivo