Biochimica Opos Spa

Farmabios S.r.l.

Lark S.p.a.

Biochimica Ops Spa

Marco Da Col

Leone Dall'Asta

Gianfranco Cainelli

Michele Contento

Irene Resta

Mauro Panunzio

Achille Umani Ronchi

Sergio Sandri

Achille Umani-Ronchi

Filippo La Loggia

Giuseppe Cantarini

Goffredo A Bolis

Process for the preparation of fluorosteroids

Described herein is the isomerisation process of 6&bgr;-fluorosteroids into the corresponding pharmacologically active 6&agr;-fluoro derivatives, comprising the reaction of 6&bgr;-fluorosteroids, or 6&agr;/6&bgr; isomeric mixtures, with an organic base containing a diazoimino group in a suitable organic solvent.

Isomerisation of 6&bgr;-fluorosteroids into the corresponding 6&agr;-fluoro derivatives

The present invention refers to process for the preparation of a tiazoline-azetidinone of formula I ##STR1## which comprises N-protecting in position 1 of (3S,4S)-3-phenylace tamido-4-acetoxy-azetidin-2-one, converting the product thus obtained into the corresponding thioamide and subsequently ciclyzing and deprotecting.

Process for the preparation of a thiazoline-azetidinone

The preparation of a novel crystalline cefaclor and the conversion of such a product to cefaclor monohydrate are described. The new intermediate cefaclor is a particular crystalline form and possesses the same antibiotic properties as cefaclor monohydrate.

Crystalline form of a cephalosporin antibiotic

There is described the preparation of halogenated .beta.-lactam derivatives by introduction of a chlorine atom in the 3-position of the cephem nucleus starting from a 3-sulfonyloxycephem. Such starting materials are reacted with a chlorine ions donor in a basic medium.

Process for the preparation of halogenated .beta.-lactam compounds

A method for the removal of the formyl group from an ester of an N-formyl peptide or N-formyl aminoacid, in which the ester is reacted with urea in the presence of a polar solvent and a strong acid.

Method for the removal of the formyl group from an ester of an N-formyl

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Bologna, Italy

Marco Da Col