Deutsches Krebsforschungszentrum

Deutsches Krebsforschungszentrum Stiftung Des Offentlichen Rechts

Iomx Therapeutics Ag

Marco Breinig

Michael Boutros

Philipp Beckhove

Nisit Khandelwal

Peter Sennhenn

Sebastian Meier-ewert

Valentina Volpin

Ayse Nur Menevse

Antonio Sorrentino

Tillmann Michels

The invention is based on the surprising finding that SIK3 is associated with resistance against anti-tumour immune responses. In particular, the invention provides methods for treating proliferative diseases using inhibitors of SIK3, especially nucleic acid or small molecule inhibitors of SIK3. Also provided are methods of sensitising cells involved with a proliferative disorder against the cytotoxic effect of certain pro-inflammatory signalling pathways, and/or to kill such cells and/or methods for treating proliferative diseases, using a SIK3 inhibitor together with ligands or agonists of such signalling pathways. Other methods provided by the invention include those involving SIK3 inhibitors to enhance or overcome certain side effects associated with treatments that utilise such signalling pathways, as well as diagnostic, prognostic and monitoring methods and kits based on the detection of SIK3 in a sample obtained from a subject, and screening methods useful for identifying or characterising inhibitors of SIK3.

Intracellular kinase associated with resistance against anti-tumour immune responses, and uses thereof

The present invention relates to a compound selectively binding to a sensory receptor or selectively altering the expression of a sensory receptor for use in a method for treating or preventing a disease associated with a pathologic cellular cytotoxic T cell (CTL) response. Further, the invention relates to means for detecting a sensory receptor for use in a method for diagnosing cellular resistance against CTL response in a patient. The invention further embraces a method for determining the resistance of a cell against a CTL response in vitro and to a method for identifying agents that influence the response of cells to CTLs.

Cytotoxic T cell response modifiers

Growing community of inventors

Bad Rappenau, Germany

Marco Breinig