Recordati Industria Chimica E Farmaceutica S.p.a.

Marco Barchielli

Paolo Colombo

Greta Adorni

Alessandra Rossi

Sergio Menegon

Fabio Berlati

Matteo Cerea

Alberto Mattei

Pierluigi Farina

Alessandra Maroni

Andrea Gazzaniga

Diego Provvedini

Fabio Sonvico

An inhalable microparticles having cysteamine hyaluronate salt is provided. Also a preparation method and a pharmaceutical composition thereof are provided.

Salt of cysteamine for the preparation of highly respirable particles

A prolonged release multiple unit dosage form, preferably pellets, of cysteamine, cystamine or a pharmaceutically acceptable salt thereof, preferably cysteamine bitartrate, with a non gastro-resistant coating is described. The dosage form is particularly indicated for the administration to patients once or twice a day and it can be used also for pediatric administration.

Prolonged release pharmaceutical composition comprising cysteamine or salt thereof

The present invention relates to a pharmaceutical formulation suitable for parenteral administration containing carglumic acid and a buffering agent having a pKfrom 5.5 to 9.0 at 25&#xb0; C.; according to an embodiment, the buffering agent may have a pKfrom 7.5 to 8.5, preferably a pKof about 8.07, such as trometamol. The formulation may also contain at least one bulking agent, such as mannitol. The invention also includes a method for manufacturing a lyophilised sterile formulation by freeze-drying a water solution containing carglumic acid, a buffering agent having a pKfrom 5.5 to 9.0 at 25&#xb0; C., preferably from 7.5 to 8.5, and optionally a bulking agent to obtain a freeze-dried powder.

Pharmaceutical parenteral formulation containing carglumic acid

Oral cysteamine formulation consisting of dry layered lipid matrix microparticles useful for treating cystinosis and neurodegenerative disorders are described.

Formulations of cysteamine and cysteamine derivatives

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Arese, Italy

Marco Barchielli