Chemelectiva Srl

Cerbios-pharma Sa

Hc-pharma Ag

Marco Baratella

Graziano Castaldi

Mauro Gaboardi

Giuseppe Pallanza

Erminio Oldani

Marta Castaldi

The present invention relates to a process for the synthesis of cysteamine or a salt thereof.

Process for the preparation of a sulfur-amine

A process for the synthesis of Sofosbuvir is provided comprising the steps of selectively mono-deacetylating a compound of formula (V) enzymatically using a resin supported lipase B derived fromto obtain a compound formula (IV), then converting the compound of formula (IV) to a compound of formula (II) by reacting the compound of formula (IV) with a compound of formula (III), and then converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.

Process for the preparation of sofosbuvir

A process for the preparation of Erlotinib is disclosed in which the compound of formula (II)  and the reaction product is subsequently treated with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride.

Process for the preparation of erlotinib

The present invention relates to a novel polymorphic form of Fexofenadine hydrochloride, to a process for preparing it, to pharmaceutical compositions containing it, as well as its use. The invention also relates to intermediates useful for the preparation of Fexofenadine hydrochloride, antihistamine drug used in the treatment of allergy symptoms.

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Cerano, Italy

Marco Baratella