Lunaphore Technologies Sa

Marco Ammann

Diego Gabriel Dupouy

Ata Tuna Ciftlik

Pierre Joris

Giulia Cappi

Marta Comino

Deniz Eroglu

Amy Jones

Emmanuel Dorel

Benjamin Pelz

Déborah Heintze

Biological sample processing system comprising an imaging unit () comprising a digital image processing system and at least one microscope including at least one lens (), a sample processing station () comprising a handling platform () including a support () and a displacement mechanism for moving the support (), and a sample processing unit () mounted on the handling platform (). The sample processing unit () comprises a tissue slide holder () for mounting thereon a tissue slide () with a biological sample () fixed thereon and a microfluidic cartridge holder () for mounting a microfluidic cartridge () thereon. The tissue slide holder () is coupled to the microfluidic cartridge holder () via a coupling () allowing the microfluidic cartridge and the tissue support to be mounted and removed from the sample processing unit in an opened position, and in a closed position for the tissue support () to be in sealing contact with the microfluidic cartridge (). The sample processing station comprises a plurality of said sample processing units mounted on the handling platform () and moveable from a position allowing mounting of the tissue slide, respectively microfluidic cartridge, or removal thereof, to a position in which the viewing window in the microfluidic cartridge holder () is positioned in alignment with the lens of said at least one microscope.

Biological sample processing system and microfluidic cartridge therefor

The invention relates to a device and method for in situ temperature-induced antigen retrieval of samples wherein all steps are performed under a pressure higher than the atmospheric pressure on a sample immobilized on a sample support which can be further subjected to staining and imaging on the same sample support, optionally by cycle multiplexing that enables imaging of various molecular targets through multi-molecular read-outs on the same sample in a rapid, highly sensitive and reliable manner.

Methods of in situ antigen retrieval of a biological sample and imaging thereof

Microfluidic cartridge () comprising a sampling device () having a sealing ring () arranged to form a microfluidic chamber () when a support containing a biological sample is brought into contact with the sealing ring, and a microfluidic network device () configured to supply reagents to the microfluidic chamber. The sampling device further comprises inlet and outlet distribution networks () in fluid communication with the microfluidic chamber and a slide holder () to guide and position said support containing a biological sample on the sampling device. The microfluidic network device comprises a plurality of reagent inlet channels () fluidly connectable to reagent sources, at least one reagent outlet channel () fluidly connected to the sampling device inlet distribution network (), and a plurality of valves () operable to selectively connect the inlet channels to the at least one outlet channel. The sampling device () and microfluidic network device () are formed on a common microfluidic support () as a single part.

Microfluidic cartridge with built-in sampling device

Diagnostic apparatus for medical or laboratory use

Growing community of inventors

Lausanne, Switzerland

Marco Ammann