Amgen Inc.

Medarex Inc.

Marco A Coccia

Jonathan Kay

Dorothy McCabe

Richard Newmark

Haichun Huang

David J King

Josephine M Cardarelli

Jonathan Alexander Terrett

Chin Pan

Li-Sheng Lu

Jonathan Alexander Terret

David John King

Dorothy Mccabe

The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to CD70 with high affinity. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for treating cancer, autoimmune disease, inflammation and viral infections.

Human monoclonal antibodies to CD70

The invention relates to methods of treating a blood disorder in a mammal with an interleukin-1 (IL-1) inhibitor. The invention also relates to methods of treating a blood disorder in a mammal with an IL-1 inhibitor, a TNF inhibitor and an erythropoietin (EPO) receptor agonist. The invention also relates to compositions of an IL-1 inhibitor and compositions of an IL-1 inhibitor, a TNF inhibitor and an EPO receptor agonist.

Method of treating anemia by administering IL-1ra

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Camarillo, CA, United States of America

Marco A Coccia