Biolab Sanus Farmaceutica Ltda

Biolab Sanus Farmaceutical Ltda.

Marcio Henrique Zaim

Sérgio Luiz Sacurai

Carlos Eduardo Da Costa Touzarim

Carlos Eduardo Touzarim

Artur Franz Keppler

This invention describes new antifungal compounds that are aralkyl benzyl ethers of the formula (I): where Ar represents aryl, imidazolil, 1,2,4-triazolyl, benzimidazolil;R, R, Rand Rare independently hydrogen, halogen, Calkyl;Rrepresents halogen, Calkyl or O&#x2014;R' where R&#x2032; represents hydrogen or lower alkyl;Rrepresents aryl, substituted aryl, trifluoromethyl, trichloromethyl or O&#x2014;R&#x2032; where R&#x2032; represents hydrogen or lower alkyl; being the substituents of the aryl a halogen or a radical tetrazolyl;n and m represent independently an integer between 0 and 5;With the proviso that when Ar is imidazolil, Ris chlorine, Ris p-phenyl and R, R, Rand Rare hydrogen, n must be different from 2. When n and m are not 0 and 1, Ror Rcan be represented by substituents not necessarily equal.

Benzyl aralkyl ether compounds, method for preparing same, intermediate compounds, use of said compounds, method for treatment and/or prevention, pharmaceutical composition and medicament containing same

The present invention describes a series of derivatives of 2-(3-methylenedioxy)-benzoyl indol, their mixtures, their pharmaceutically acceptable salts, their enantiomers, pharmaceutical compositions comprising them, processes for preparing them, use in the prophylactic and/or curative treatment of sexual dysfunction. More specifically, the invention describes derivatives (R)-3-((2-(benzo[d][1,3]dioxol-5-carbonyl)-1H-indol-3-yl)methyl)-1-methylpiperazine-2,5-dione, and S)-3-((2-(benzo[d][1,3]dioxol-5-carbonyl)-1H-indol-3-yl)methyl)-1-methylpiperazine-2,5-dione.

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São Paulo-SP, Brazil

Marcio Henrique Zaim