Boston Scientific Scimed, Inc.

Scimed Life Systems, Inc.

Marcia McBride-Sakal

Charles Pugsley

Kurt Geitz

Michael S Banik

Kathleen M Miller

Endoluminally delivered tissue patches and related systems and methods for delivering the tissue patches for treating lesions of the alimentary tract are disclosed. A tissue patch includes a substrate, a tissue implant attached to the substrate, and a protective liner covering at least a portion of the tissue implant. A method includes providing a tissue patch having a tissue implant attached to a substrate and a protective liner covering at least a portion of the tissue implant. The tissue patch is formed into a contracted state and inserted into a lumen containing the lesion. The tissue patch then is positioned in the vicinity of the lesion. After removing the protective liner to reveal the tissue implant, the tissue implant is placed in the lesion.

Tissue patches and related delivery systems and methods

A tissue patch for treatment of a lesion in an alimentary tract of a patient includes a tissue implant having a top surface and a bottom surface. The tissue patch also includes a substrate completely surrounding the tissue implant such that the substrate forms a first layer on the top surface and a second layer on the bottom surface. At least one of the first and second layers contacts the respective top or bottom surface and is entirely bio-absorbable so that the tissue implant touches an area of the patient's tissue upon dissolving of the at least one of the first and second layers. The first layer has a first predetermined thickness and the second layer has a second predetermined thickness different from the first predetermined thickness.

A ligating band according to the present invention comprises an elastomeric layer and an inner drug releasing layer. The inner drug releasing layer includes a therapeutic agent, for example a chemotherapeutic agent for treating a mucosa, polyp or other growth. A ligating band according to the present invention also may include an inner diffusion barrier disposed between the elastomeric layer and the inner drug releasing layer, with the elastomeric layer and the inner drug releasing layer each contacting the inner diffusion barrier.

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Bolton, MA, United States of America

Marcia McBride-Sakal